|Hexanucleotide repeats in ALS/FTD form length-dependent RNA foci, sequester RNA binding proteins, and are neurotoxic|
YB Lee, HJ Chen, JN Peres, J Gomez-Deza, J Attig, M Štalekar, ...
Cell reports 5 (5), 1178-1186, 2013
|Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: a mechanism for receptor cross-talk?|
CS Kearn, K Blake-Palmer, E Daniel, K Mackie, M Glass
Molecular pharmacology 67 (5), 1697-1704, 2005
|Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS|
BN Smith, N Ticozzi, C Fallini, AS Gkazi, S Topp, KP Kenna, EL Scotter, ...
Neuron 84 (2), 324-331, 2014
|TDP-43 proteinopathy and ALS: insights into disease mechanisms and therapeutic targets|
EL Scotter, HJ Chen, CE Shaw
Neurotherapeutics 12 (2), 352-363, 2015
|Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species|
EL Scotter, C Vance, AL Nishimura, YB Lee, HJ Chen, H Urwin, ...
Journal of cell science 127 (6), 1263-1278, 2014
|ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules|
C Vance, EL Scotter, AL Nishimura, C Troakes, JC Mitchell, C Kathe, ...
Human molecular genetics 22 (13), 2676-2688, 2013
|The endocannabinoid system as a target for the treatment of neurodegenerative disease|
EL Scotter, ME Abood, M Glass
British journal of pharmacology 160 (3), 480-498, 2010
|Distant structural homology leads to the functional characterization of an archaeal PIN domain as an exonuclease|
VL Arcus, K Bäckbro, A Roos, EL Daniel, EN Baker
Journal of Biological Chemistry 279 (16), 16471-16478, 2004
|Specific detection of CB1 receptors; cannabinoid CB1 receptor antibodies are not all created equal!|
NL Grimsey, CE Goodfellow, EL Scotter, MJ Dowie, M Glass, ES Graham
Journal of neuroscience methods 171 (1), 78-86, 2008
|The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis|
HJ Chen, JC Mitchell, S Novoselov, J Miller, AL Nishimura, EL Scotter, ...
Brain 139 (5), 1417-1432, 2016
|TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function|
J Rustenhoven, M Aalderink, EL Scotter, RL Oldfield, PS Bergin, EW Mee, ...
Journal of neuroinflammation 13 (1), 1-15, 2016
|Novel mutations support a role for Profilin 1 in the pathogenesis of ALS|
BN Smith, C Vance, EL Scotter, C Troakes, CH Wong, S Topp, ...
Neurobiology of aging 36 (3), 1602. e17-1602. e27, 2015
|Markers for human brain pericytes and smooth muscle cells|
LCD Smyth, J Rustenhoven, EL Scotter, P Schweder, RLM Faull, TIH Park, ...
Journal of chemical neuroanatomy 92, 48-60, 2018
|Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis|
BN Smith, SD Topp, C Fallini, H Shibata, HJ Chen, C Troakes, A King, ...
Science translational medicine 9 (388), 2017
|Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS|
JC Mitchell, R Constable, E So, C Vance, E Scotter, L Glover, ...
Acta neuropathologica communications 3 (1), 1-16, 2015
|Neuroprotective potential of CB1 receptor agonists in an in vitro model of Huntington's disease|
EL Scotter, CE Goodfellow, ES Graham, M Dragunow, M Glass
British journal of pharmacology 160 (3), 747-761, 2010
|Induction of Krox-24 by endogenous cannabinoid type 1 receptors in Neuro2A cells is mediated by the MEK-ERK MAPK pathway and is suppressed by the phosphatidylinositol 3-kinase …|
ES Graham, N Ball, EL Scotter, P Narayan, M Dragunow, M Glass
Journal of Biological Chemistry 281 (39), 29085-29095, 2006
|Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells|
AL Nishimura, C Shum, EL Scotter, A Abdelgany, V Sardone, J Wright, ...
PloS one 9 (3), e91269, 2014
|PU. 1 regulates Alzheimer’s disease-associated genes in primary human microglia|
J Rustenhoven, AM Smith, LC Smyth, D Jansson, EL Scotter, ...
Molecular neurodegeneration 13 (1), 1-16, 2018
|An anti-inflammatory role for C/EBPδ in human brain pericytes|
J Rustenhoven, EL Scotter, D Jansson, DT Kho, RL Oldfield, PS Bergin, ...
Scientific reports 5 (1), 1-14, 2015