| Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor M Hirsila, P Koivunen, V Gunzler, KI Kivirikko, J Myllyharju Journal of Biological Chemistry 278 (33), 30772-30780, 2003 | 973 | 2003 |
| Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation P Koivunen, S Lee, CG Duncan, G Lopez, G Lu, S Ramkissoon, ... Nature 483 (7390), 484-488, 2012 | 820 | 2012 |
| (R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible JA Losman, RE Looper, P Koivunen, S Lee, RK Schneider, C McMahon, ... Science 339 (6127), 1621-1625, 2013 | 767 | 2013 |
| Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF P Koivunen, M Hirsilä, AM Remes, IE Hassinen, KI Kivirikko, J Myllyharju Journal of Biological Chemistry 282 (7), 4524-4532, 2007 | 637 | 2007 |
| Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases P Koivunen, M Hirsilä, V Günzler, KI Kivirikko, J Myllyharju Journal of Biological Chemistry 279 (11), 9899-9904, 2004 | 538 | 2004 |
| A genetic mechanism for Tibetan high-altitude adaptation FR Lorenzo, C Huff, M Myllymäki, B Olenchock, S Swierczek, T Tashi, ... Nature genetics 46 (9), 951-956, 2014 | 421 | 2014 |
| Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate AA Chakraborty, T Laukka, M Myllykoski, AE Ringel, MA Booker, ... Science 363 (6432), 1217-1222, 2019 | 342 | 2019 |
| Fumarate and succinate regulate expression of hypoxia-inducible genes via TET enzymes T Laukka, CJ Mariani, T Ihantola, JZ Cao, J Hokkanen, WG Kaelin, ... Journal of Biological Chemistry 291 (8), 4256-4265, 2016 | 305 | 2016 |
| Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway M Hirsilä, P Koivunen, L Xu, T Seeley, KI Kivirikko, J Myllyharju The FASEB Journal 19 (10), 1308-1310, 2005 | 267 | 2005 |
| Paracrine induction of HIF by glutamate in breast cancer: EglN1 senses cysteine KJ Briggs, P Koivunen, S Cao, KM Backus, BA Olenchock, H Patel, ... Cell 166 (1), 126-139, 2016 | 198 | 2016 |
| The prognostic significance and value of cyclin D1, CDK4 and p16 in human breast cancer E Peurala, P Koivunen, KM Haapasaari, R Bloigu, A Jukkola-Vuorinen Breast Cancer Research 15, 1-10, 2013 | 182 | 2013 |
| An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor α P Koivunen, P Tiainen, J Hyvärinen, KE Williams, R Sormunen, ... Journal of Biological Chemistry 282 (42), 30544-30552, 2007 | 174 | 2007 |
| The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases P Koivunen, M Hirsilä, KI Kivirikko, J Myllyharju Journal of Biological Chemistry 281 (39), 28712-28720, 2006 | 161 | 2006 |
| HIF-1α is upregulated in human mesenchymal stem cells S Palomäki, M Pietilä, S Laitinen, J Pesälä, R Sormunen, P Lehenkari, ... Stem cells 31 (9), 1902-1909, 2013 | 146 | 2013 |
| 2-Oxoglutarate-dependent dioxygenases in cancer JA Losman, P Koivunen, WG Kaelin Jr Nature Reviews Cancer 20 (12), 710-726, 2020 | 143 | 2020 |
| Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase X Zheng, B Zhai, P Koivunen, SJ Shin, G Lu, J Liu, C Geisen, ... Genes & development 28 (13), 1429-1444, 2014 | 136 | 2014 |
| Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury J Hyvärinen, IE Hassinen, R Sormunen, JM Mäki, KI Kivirikko, P Koivunen, ... Journal of biological chemistry 285 (18), 13646-13657, 2010 | 133 | 2010 |
| HIF prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction L Rahtu-Korpela, S Karsikas, S Hörkkö, R Blanco Sequeiros, ... Diabetes 63 (10), 3324-3333, 2014 | 122 | 2014 |
| The primary substrate binding site in the b′ domain of ERp57 is adapted for endoplasmic reticulum lectin association SJ Russell, LW Ruddock, KEH Salo, JD Oliver, QP Roebuck, ... Journal of Biological Chemistry 279 (18), 18861-18869, 2004 | 122 | 2004 |
| Characterization of a second Arabidopsis thaliana prolyl 4-hydroxylase with distinct substrate specificity P Tiainen, J Myllyharju, P Koivunen Journal of Biological Chemistry 280 (2), 1142-1148, 2005 | 120 | 2005 |
