Sensitivity, robustness, and identifiability in stochastic chemical kinetics models M Komorowski, MJ Costa, DA Rand, MPH Stumpf Proceedings of the National Academy of Sciences 108 (21), 8645, 2011 | 244 | 2011 |
Maximizing the information content of experiments in systems biology J Liepe, S Filippi, M Komorowski, MPH Stumpf PLoS computational biology 9 (1), e1002888, 2013 | 222 | 2013 |
Bayesian inference of biochemical kinetic parameters using the linear noise approximation M Komorowski, B Finkenstädt, C Harper, D Rand BMC bioinformatics 10 (1), 343, 2009 | 159 | 2009 |
Reconstruction of transcriptional dynamics from gene reporter data using differential equations B Finkenstädt, EA Heron, M Komorowski, K Edwards, S Tang, CV Harper, ... Bioinformatics 24 (24), 2901-2907, 2008 | 85 | 2008 |
Nitrogen and Carbon Status Are Integrated at the Transcriptional Level by the Nitrogen Regulator NtrC In Vivo J Schumacher, V Behrends, Z Pan, DR Brown, F Heydenreich, MR Lewis, ... MBio 4 (6), 10.1128/mbio. 00881-13, 2013 | 65 | 2013 |
Quantifying intrinsic and extrinsic noise in gene transcription using the linear noise approximation: An application to single cell data B Finkenstädt, DJ Woodcock, M Komorowski, CV Harper, JRE Davis, ... The Annals of Applied Statistics, 1960-1982, 2013 | 54 | 2013 |
Decomposing Noise in Biochemical Signaling Systems Highlights the Role of Protein Degradation M Komorowski, J Miekisz, MPH Stumpf Biophysical Journal 104 (8), 1783-93, 2013 | 51 | 2013 |
Information-theoretic analysis of multivariate single-cell signaling responses T Jetka, K Nienałtowski, T Winarski, S Błoński, M Komorowski PLoS computational biology 15 (7), e1007132, 2019 | 44 | 2019 |
Nuclear translocation of STAT3 and NF-κB are independent of each other but NF-κB supports expression and activation of STAT3 A Martincuks, K Andryka, A Küster, H Schmitz-Van de Leur, ... Cellular signalling 32, 36-47, 2017 | 43 | 2017 |
Translational repression contributes greater noise to gene expression than transcriptional repression M Komorowski, J Miekisz, AM Kierzek Biophysical Journal 96 (2), 372-384, 2009 | 43 | 2009 |
Robustness and information transfer within IL-6-induced JAK/STAT signalling U Billing, T Jetka, L Nortmann, N Wundrack, M Komorowski, S Waldherr, ... Communications biology 2 (1), 27, 2019 | 42 | 2019 |
Quantitative biology: theory, computational methods, and models B Munsky, WS Hlavacek, LS Tsimring MIT Press, 2018 | 40 | 2018 |
Using a single fluorescent reporter gene to infer half-life of extrinsic noise and other parameters of gene expression M Komorowski, B Finkenstädt, D Rand Biophysical journal 98 (12), 2759-2769, 2010 | 37 | 2010 |
An information-theoretic framework for deciphering pleiotropic and noisy biochemical signaling T Jetka, K Nienałtowski, S Filippi, MPH Stumpf, M Komorowski Nature communications 9 (1), 4591, 2018 | 33 | 2018 |
The tyrosine phosphatase SHP2 increases robustness and information transfer within IL-6-induced JAK/STAT signalling J Fiebelkow, A Guendel, B Guendel, N Mehwald, T Jetka, M Komorowski, ... Cell Communication and Signaling 19, 1-19, 2021 | 32 | 2021 |
The limited information capacity of cross-reactive sensors drives the evolutionary expansion of signaling M Komorowski, DS Tawfik Cell systems 8 (1), 76-85. e6, 2019 | 27 | 2019 |
Phenotypic variability, not noise, accounts for most of the cell-to-cell heterogeneity in IFN-γ and oncostatin M signaling responses P Topolewski, KE Zakrzewska, J Walczak, K Nienałtowski, ... Science Signaling 15 (721), eabd9303, 2022 | 23 | 2022 |
Mathematical modeling reveals the functional implications of the different nuclear shuttling rates of Erk1 and Erk2 HA Harrington, M Komorowski, M Beguerisse-Díaz, GM Ratto, ... Physical biology 9 (3), 036001, 2012 | 23 | 2012 |
StochSens—matlab package for sensitivity analysis of stochastic chemical systems M Komorowski, J Žurauskienė, MPH Stumpf Bioinformatics 28 (5), 731-733, 2012 | 23 | 2012 |
Clustering reveals limits of parameter identifiability in multi-parameter models of biochemical dynamics M Włodarczyk, T Lipniacki, M Komorowski BMC Systems Biology 9 (65), 2015 | 19* | 2015 |