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Edgar Otto, PhD
Edgar Otto, PhD
Associate Research Scientist, Internal Medicine-Nephrology, University of Michigan
Verified email at umich.edu
Title
Cited by
Cited by
Year
Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination
EA Otto, B Schermer, T Obara, JF O'Toole, KS Hiller, AM Mueller, RG Ruf, ...
Nature genetics 34 (4), 413-420, 2003
7522003
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4
JA Sayer, EA Otto, JF O'Toole, G Nurnberg, MA Kennedy, C Becker, ...
Nature genetics 38 (6), 674-681, 2006
7372006
A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition
FR Garcia-Gonzalo, KC Corbit, MS Sirerol-Piquer, G Ramaswami, EA Otto, ...
Nature genetics 43 (8), 776-784, 2011
7222011
Barttin is a Cl- channel β-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion
R Estévez, T Boettger, V Stein, R Birkenhäger, E Otto, F Hildebrandt, ...
Nature 414 (6863), 558-561, 2001
7022001
Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible
B Hinkes, RC Wiggins, R Gbadegesin, CN Vlangos, D Seelow, ...
Nature genetics 38 (12), 1397-1405, 2006
6792006
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways
L Sang, JJ Miller, KC Corbit, RH Giles, MJ Brauer, EA Otto, LM Baye, ...
Cell 145 (4), 513-528, 2011
6732011
Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure
R Birkenhäger, E Otto, MJ Schürmann, M Vollmer, EM Ruf, I Maier-Lutz, ...
Nature genetics 29 (3), 310-314, 2001
6202001
SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1–SIX1–DNA complexes
RG Ruf, PX Xu, D Silvius, EA Otto, F Beekmann, UT Muerb, S Kumar, ...
Proceedings of the National Academy of Sciences 101 (21), 8090-8095, 2004
5102004
Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin
EA Otto, B Loeys, H Khanna, J Hellemans, R Sudbrak, S Fan, U Muerb, ...
Nature genetics 37 (3), 282-288, 2005
4612005
Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis
H Olbrich, M Fliegauf, J Hoefele, A Kispert, E Otto, A Volz, MT Wolf, ...
Nature genetics 34 (4), 455-459, 2003
4522003
Mutations in the cilia gene ARL13B lead to the classical form of Joubert syndrome
V Cantagrel, JL Silhavy, SL Bielas, D Swistun, SE Marsh, JY Bertrand, ...
The American Journal of Human Genetics 83 (2), 170-179, 2008
4362008
Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling
M Chaki, R Airik, AK Ghosh, RH Giles, R Chen, GG Slaats, H Wang, ...
Cell 150 (3), 533-548, 2012
4352012
High-throughput screening enhances kidney organoid differentiation from human pluripotent stem cells and enables automated multidimensional phenotyping
SM Czerniecki, NM Cruz, JL Harder, R Menon, J Annis, EA Otto, ...
Cell stem cell 22 (6), 929-940. e4, 2018
4262018
In-frame deletion in a novel centrosomal/ciliary protein CEP290/NPHP6 perturbs its interaction with RPGR and results in early-onset retinal degeneration in the rd16 mouse
B Chang, H Khanna, N Hawes, D Jimeno, S He, C Lillo, SK Parapuram, ...
Human molecular genetics 15 (11), 1847-1857, 2006
4242006
TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum
EE Davis, Q Zhang, Q Liu, BH Diplas, LM Davey, J Hartley, C Stoetzel, ...
Nature genetics 43 (3), 189-196, 2011
4192011
A novel gene encoding an SH3 domain protein is mutated in nephronophthisis type 1
F Hildebrandt, E Otto, C Rensing, HG Nothwang, M Vollmer, J Adolphs, ...
Nature genetics 17 (2), 149-153, 1997
4081997
Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy
EA Otto, TW Hurd, R Airik, M Chaki, W Zhou, C Stoetzel, SB Patil, S Levy, ...
Nature genetics 42 (10), 840-850, 2010
3922010
ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption
S Ashraf, HY Gee, S Woerner, LX Xie, V Vega-Warner, S Lovric, H Fang, ...
The Journal of clinical investigation 123 (12), 5179-5189, 2013
3832013
Cilia and centrosomes: a unifying pathogenic concept for cystic kidney disease?
F Hildebrandt, E Otto
Nature Reviews Genetics 6 (12), 928-940, 2005
3722005
An atlas of healthy and injured cell states and niches in the human kidney
BB Lake, R Menon, S Winfree, Q Hu, R Melo Ferreira, K Kalhor, ...
Nature 619 (7970), 585-594, 2023
3532023
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