Meritxell Huch
Meritxell Huch
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Organoid models of human and mouse ductal pancreatic cancer
SF Boj, CI Hwang, LA Baker, IIC Chio, DD Engle, V Corbo, M Jager, ...
Cell 160 (1), 324-338, 2015
Lgr5+ ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro
N Barker, M Huch, P Kujala, M van de Wetering, HJ Snippert, JH van Es, ...
Cell stem cell 6 (1), 25-36, 2010
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
M Huch, C Dorrell, SF Boj, JH Van Es, VSW Li, M Van De Wetering, ...
Nature 494 (7436), 247-250, 2013
Long-term culture of genome-stable bipotent stem cells from adult human liver
M Huch, H Gehart, R Van Boxtel, K Hamer, F Blokzijl, MMA Verstegen, ...
Cell 160 (1), 299-312, 2015
Human primary liver cancer–derived organoid cultures for disease modeling and drug screening
L Broutier, G Mastrogiovanni, MMA Verstegen, HE Francies, LM Gavarró, ...
Nature medicine 23 (12), 1424-1435, 2017
Tissue-specific mutation accumulation in human adult stem cells during life
F Blokzijl, J De Ligt, M Jager, V Sasselli, S Roerink, N Sasaki, M Huch, ...
Nature 538 (7624), 260-264, 2016
In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection
S Bartfeld, T Bayram, M van de Wetering, M Huch, H Begthel, P Kujala, ...
Gastroenterology 148 (1), 126-136. e6, 2015
Unlimited in vitro expansion of adult bi‐potent pancreas progenitors through the Lgr5/R‐spondin axis
M Huch, P Bonfanti, SF Boj, T Sato, CJM Loomans, M Van De Wetering, ...
The EMBO journal 32 (20), 2708-2721, 2013
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation
L Broutier, A Andersson-Rolf, CJ Hindley, SF Boj, H Clevers, BK Koo, ...
Nature protocols 11 (9), 1724-1743, 2016
Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium
DE Stange, BK Koo, M Huch, G Sibbel, O Basak, A Lyubimova, P Kujala, ...
Cell 155 (2), 357-368, 2013
Modeling mouse and human development using organoid cultures
M Huch, BK Koo
Development 142 (18), 3113-3125, 2015
The hope and the hype of organoid research
M Huch, JA Knoblich, MP Lutolf, A Martinez-Arias
Development 144 (6), 938-941, 2017
Genome sequencing of normal cells reveals developmental lineages and mutational processes
S Behjati, M Huch, R Van Boxtel, W Karthaus, DC Wedge, AU Tamuri, ...
Nature 513 (7518), 422-425, 2014
Controlled gene expression in primary Lgr5 organoid cultures
BK Koo, DE Stange, T Sato, W Karthaus, HF Farin, M Huch, JH Van Es, ...
Nature methods 9 (1), 81-83, 2012
Disease modelling in human organoids
MA Lancaster, M Huch
Disease models & mechanisms 12 (7), dmm039347, 2019
Z Zhao, X Chen, AM Dowbaj, A Sljukic, K Bratlie, L Lin, ELS Fong, ...
Nature Reviews Methods Primers 2 (1), 94, 2022
Liver organoids: from basic research to therapeutic applications
N Prior, P Inacio, M Huch
Gut 68 (12), 2228-2237, 2019
Lgr5+ ve stem/progenitor cells contribute to nephron formation during kidney development
N Barker, MB Rookmaaker, P Kujala, A Ng, M Leushacke, H Snippert, ...
Cell reports 2 (3), 540-552, 2012
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand
SF Boj, JH van Es, M Huch, VSW Li, A José, P Hatzis, M Mokry, ...
Cell 151 (7), 1595-1607, 2012
The balancing act of the liver: tissue regeneration versus fibrosis
L Cordero-Espinoza, M Huch
The Journal of clinical investigation 128 (1), 85-96, 2018
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