Eva R Hoffmann

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Laura RienziScientific Director GeneraVerified email at generapma.it
Claus Yding AndersenProfessor i human reproduktionsfysiologiVerified email at rh.dk
Filippo Maria UbaldiClinical Director Centres for Reproductive Medicine GENERAVerified email at generaroma.it
Alan HandysidePrincipal Scientist, Illumina, Cambridge, UKVerified email at thebridgecentre.co.uk
Carlos SimonProfessor of Obs/Gyn; University of Valencia. Head of Scientific Advisory Board, Igenomix SLVerified email at igenomix.com
Simone Engmann HildorfDepartment of Paediatric Surgery, Surgical Clinic C, Copenhagen University Hospital RigshospitaletVerified email at regionh.dk
Lihua DongRigshospitaletVerified email at regionh.dk
Dina CortesDepartment of Pediatrics, Hvidovre University Hospital and University of CopenhagenVerified email at regionh.dk
jorgen thorupProfessor in Surgery (Pediatrics), Rigshospitalet, University of CopenhagenVerified email at rh.dk
Nina la Cour FreieslebenDep. of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital HvidovreVerified email at regionh.dk
Darren GriffinProfessor of Genetics, University of KentVerified email at kent.ac.uk
Stine Gry KristensenLaboratory of Reproductive BiologyVerified email at regionh.dk
Murat GulSelcuk University School of MedicineVerified email at selcuk.edu.tr
Sine BerntsenM.D, Research assistant, Hvidovre Hospital, DenmarkVerified email at regionh.dk
Henrik WesthProfessor i klinisk mikrobiologi, Københavns UniversitetVerified email at regionh.dk
Henriette Svarre NielsenProfessor dept. Clinical Medicine, University of Copenhagen, Consultant and Head of RecurrentVerified email at regionh.dk
Rajiv McCoyAssistant Professor of Biology, Johns Hopkins UniversityVerified email at jhu.edu
David Westergaard, PhDSenior Researcher, Hvidovre Hospital. Assistant Professor, University of CopenhagenVerified email at regionh.dk
Andreas InghamPh.D.-student, Novo Nordisk Foundation Center for Protein Research, UCPHVerified email at cpr.ku.dk
Rehannah Borup Helweg-LarsenBioinformatician/Molecular Biologist, PhDVerified email at rh.dk

Eva R Hoffmann

DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine (ICMM)

Verified email at sund.ku.dk

meiosis chromosome segregation aneuploidy DDR


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Chromosome errors in human eggs shape natural fertility over reproductive life span JR Gruhn, AP Zielinska, V Shukla, R Blanshard, A Capalbo, D Cimadomo, ... Science 365 (6460), 1466-1469, 2019	278	2019
Genome-wide maps of recombination and chromosome segregation in human oocytes and embryos show selection for maternal recombination rates CS Ottolini, LJ Newnham, A Capalbo, SA Natesan, HA Joshi, ... Nature genetics 47 (7), 727-735, 2015	270	2015
Human female meiosis revised: new insights into the mechanisms of chromosome segregation and aneuploidies from advanced genomics and time-lapse imaging A Capalbo, ER Hoffmann, D Cimadomo, F Maria Ubaldi, L Rienzi Human reproduction update 23 (6), 706-722, 2017	222	2017
Genetic predisposition to mosaic Y chromosome loss in blood DJ Thompson, G Genovese, J Halvardson, JC Ulirsch, DJ Wright, C Terao, ... Nature 575 (7784), 652-657, 2019	214	2019
Genetic insights into biological mechanisms governing human ovarian ageing KS Ruth, FR Day, J Hussain, A Martínez-Marchal, CE Aiken, A Azad, ... Nature 596 (7872), 393-397, 2021	213	2021
FindFoci: a focus detection algorithm with automated parameter training that closely matches human assignments, reduces human inconsistencies and increases speed of analysis AD Herbert, AM Carr, E Hoffmann PloS one 9 (12), e114749, 2014	133	2014
Mosaic human preimplantation embryos and their developmental potential in a prospective, non-selection clinical trial A Capalbo, M Poli, L Rienzi, L Girardi, C Patassini, M Fabiani, ... The American Journal of Human Genetics 108 (12), 2238-2247, 2021	128	2021
Meiotic recombination intermediates and mismatch repair proteins ER Hoffmann, RH Borts Cytogenetic and genome research 107 (3-4), 232-248, 2004	128	2004
A Mec1-and PP4-dependent checkpoint couples centromere pairing to meiotic recombination JE Falk, AC Chan, E Hoffmann, A Hochwagen Developmental cell 19 (4), 599-611, 2010	126	2010
SARS-CoV-2 in first trimester pregnancy: a cohort study N la Cour Freiesleben, P Egerup, KVR Hviid, ER Severinsen, AM Kolte, ... Human Reproduction 36 (1), 40-47, 2021	121	2021
Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control I Gallina, C Colding, P Henriksen, P Beli, K Nakamura, J Offman, ... Nature communications 6 (1), 6533, 2015	102	2015
Regulation of the MLH1–MLH3 endonuclease in meiosis E Cannavo, A Sanchez, R Anand, L Ranjha, J Hugener, C Adam, ... Nature 586 (7830), 618-622, 2020	96	2020
The synaptonemal complex protein, Zip1, promotes the segregation of nonexchange chromosomes at meiosis I L Newnham, P Jordan, B Rockmill, GS Roeder, E Hoffmann Proceedings of the National Academy of Sciences 107 (2), 781-785, 2010	87	2010
Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions A Copsey, S Tang, PW Jordan, HG Blitzblau, S Newcombe, AC Chan, ... PLoS genetics 9 (12), e1004071, 2013	84	2013
KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes A Sankar, M Lerdrup, A Manaf, JV Johansen, JM Gonzalez, R Borup, ... Nature Cell Biology 22 (4), 380-388, 2020	81	2020
Requirement for DNA ligase IV during embryonic neuronal development SA Gatz, L Ju, R Gruber, E Hoffmann, AM Carr, ZQ Wang, C Liu, ... Journal of Neuroscience 31 (27), 10088-10100, 2011	80	2011
Meiotic kinetochores fragment into multiple lobes upon cohesin loss in aging eggs AP Zielinska, E Bellou, N Sharma, AS Frombach, KB Seres, JR Gruhn, ... Current Biology 29 (22), 3749-3765. e7, 2019	72	2019
Incidence, origin, and predictive model for the detection and clinical management of segmental aneuploidies in human embryos L Girardi, M Serdarogullari, C Patassini, M Poli, M Fabiani, S Caroselli, ... The American Journal of Human Genetics 106 (4), 525-534, 2020	69	2020
Tripolar chromosome segregation drives the association between maternal genotype at variants spanning PLK4 and aneuploidy in human preimplantation embryos RC McCoy, LJ Newnham, CS Ottolini, ER Hoffmann, K Chatzimeletiou, ... Human molecular genetics 27 (14), 2573-2585, 2018	64	2018
MLH1 Mutations Differentially Affect Meiotic Functions in Saccharomyces cerevisiae ER Hoffmann, PV Shcherbakova, TA Kunkel, RH Borts Genetics 163 (2), 515-526, 2003	57	2003

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