| Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling C Chaussade, GW Rewcastle, JD Kendall, WA Denny, K Cho, ... Biochemical Journal 404 (3), 449-458, 2007 | 259 | 2007 |
| Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells H Tronchere, J Laporte, C Pendaries, C Chaussade, L Liaubet, L Pirola, ... Journal of Biological Chemistry 279 (8), 7304-7312, 2004 | 167 | 2004 |
| The level of AKT phosphorylation on threonine 308 but not on serine 473 is associated with high-risk cytogenetics and predicts poor overall survival in acute myeloid leukaemia N Gallay, C Dos Santos, L Cuzin, M Bousquet, V Simmonet Gouy, ... Leukemia 23 (6), 1029-1038, 2009 | 148 | 2009 |
| Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of … L Pirola, S Bonnafous, AM Johnston, C Chaussade, F Portis, ... Journal of Biological Chemistry 278 (18), 15641-15651, 2003 | 142 | 2003 |
| Atypical antipsychotic drugs induce derangements in glucose homeostasis by acutely increasing glucagon secretion and hepatic glucose output in the rat GC Smith, C Chaussade, M Vickers, J Jensen, PR Shepherd Diabetologia 51, 2309-2317, 2008 | 107 | 2008 |
| Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148 JR Whiteford, X Xian, C Chaussade, B Vanhaesebroeck, S Nourshargh, ... Molecular biology of the cell 22 (19), 3609-3624, 2011 | 97 | 2011 |
| Inactivation of the class II PI3K-C2β potentiates insulin signaling and sensitivity S Alliouachene, B Bilanges, G Chicanne, KE Anderson, W Pearce, K Ali, ... Cell reports 13 (9), 1881-1894, 2015 | 88 | 2015 |
| Expression of Myotubularin by an Adenoviral Vector Demonstrates Its Function as a Phosphatidylinositol 3-Phosphate [PtdIns(3)P] Phosphatase in Muscle Cell Lines … C Chaussade, L Pirola, S Bonnafous, F Blondeau, S Brenz-Verca, ... Molecular Endocrinology 17 (12), 2448-2460, 2003 | 86 | 2003 |
| Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110α inhibitors JD Kendall, GW Rewcastle, R Frederick, C Mawson, WA Denny, ... Bioorganic & medicinal chemistry 15 (24), 7677-7687, 2007 | 72 | 2007 |
| Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism B Bilanges, S Alliouachene, W Pearce, D Morelli, G Szabadkai, YL Chung, ... Nature communications 8 (1), 1804, 2017 | 69 | 2017 |
| Essential role of class II PI3K-C2α in platelet membrane morphology C Valet, G Chicanne, C Severac, C Chaussade, MA Whitehead, C Cabou, ... Blood, The Journal of the American Society of Hematology 126 (9), 1128-1137, 2015 | 63 | 2015 |
| Functional differences between two classes of oncogenic mutation in the PIK3CA gene C Chaussade, K Cho, C Mawson, GW Rewcastle, PR Shepherd Biochemical and biophysical research communications 381 (4), 577-581, 2009 | 58 | 2009 |
| Nuclear forkhead box O1 controls and integrates key signaling pathways in hepatocytes M Naïmi, N Gautier, C Chaussade, AM Valverde, D Accili, ... Endocrinology 148 (5), 2424-2434, 2007 | 56 | 2007 |
| Both p110α and p110β isoforms of phosphatidylinositol 3‐OH‐kinase are required for insulin signalling in the hypothalamus A Tups, GM Anderson, M Rizwan, RA Augustine, C Chaussade, ... Journal of neuroendocrinology 22 (6), 534-542, 2010 | 51 | 2010 |
| Calpain interacts with class IA phosphoinositide 3-kinases regulating their stability and signaling activity L Beltran, C Chaussade, B Vanhaesebroeck, PR Cutillas Proceedings of the National Academy of Sciences 108 (39), 16217-16222, 2011 | 47 | 2011 |
| Discovery of pyrazolo [1, 5-a] pyridines as p110α-selective PI3 kinase inhibitors JD Kendall, PD O’Connor, AJ Marshall, R Frédérick, ES Marshall, CL Lill, ... Bioorganic & medicinal chemistry 20 (1), 69-85, 2012 | 42 | 2012 |
| Novel pyrazolo [1, 5-a] pyridines as p110α-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR JD Kendall, AC Giddens, KY Tsang, R Frédérick, ES Marshall, R Singh, ... Bioorganic & medicinal chemistry 20 (1), 58-68, 2012 | 41 | 2012 |
| Phosphoinositide-3-kinase (PI3K) inhibitors: identification of new scaffolds using virtual screening R Frédérick, C Mawson, JD Kendall, C Chaussade, GW Rewcastle, ... Bioorganic & medicinal chemistry letters 19 (20), 5842-5847, 2009 | 33 | 2009 |
| Synthesis of Functionalized Pyrazolo [1, 5-a] pyridines:[3+ 2] Cycloaddition of N-Aminopyridines and α, β-Unsaturated Carbonyl Compounds/Alkenes at Room Temperature C Ravi, S Samanta, DC Mohan, NNK Reddy, S Adimurthy Synthesis 49 (11), 2513-2522, 2017 | 31 | 2017 |
| Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice S Alliouachene, B Bilanges, C Chaussade, W Pearce, LC Foukas, ... Diabetologia 59, 1503-1512, 2016 | 27 | 2016 |
