Michael P Hay
Michael P Hay
Associate Professor, University of Auckland
Verified email at - Homepage
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Targeting hypoxia in cancer therapy
WR Wilson, MP Hay
Nature Reviews Cancer 11 (6), 393-410, 2011
Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality
DA Chan, PD Sutphin, P Nguyen, S Turcotte, EW Lai, A Banh, ...
Science translational medicine 3 (94), 94ra70-94ra70, 2011
A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy
S Turcotte, DA Chan, PD Sutphin, MP Hay, WA Denny, AJ Giaccia
Cancer cell 14 (1), 90-102, 2008
Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs
KO Hicks, FB Pruijn, TW Secomb, MP Hay, R Hsu, JM Brown, WA Denny, ...
Journal of the National Cancer Institute 98 (16), 1118-1128, 2006
Recent developments in the design of bioreductive drugs.
WA Denny, WR Wilson, MP Hay
The British journal of cancer. Supplement 27, S32, 1996
Structure− activity relationships of 1, 2, 4-benzotriazine 1, 4-dioxides as hypoxia-selective analogues of tirapazamine
MP Hay, SA Gamage, MS Kovacs, FB Pruijn, RF Anderson, AV Patterson, ...
Journal of medicinal chemistry 46 (1), 169-182, 2003
Pharmacokinetic/Pharmacodynamic Modeling Identifies SN30000 and SN29751 as Tirapazamine Analogues with Improved Tissue Penetration and Hypoxic Cell Killing in TumorsHypoxic …
KO Hicks, BG Siim, JK Jaiswal, FB Pruijn, AM Fraser, R Patel, A Hogg, ...
Clinical Cancer Research 16 (20), 4946-4957, 2010
Activation of 3-amino-1, 2, 4-benzotriazine 1, 4-dioxide antitumor agents to oxidizing species following their one-electron reduction
RF Anderson, SS Shinde, MP Hay, SA Gamage, WA Denny
Journal of the American Chemical Society 125 (3), 748-756, 2003
Hypoxia-selective antitumor agents. 8. Bis (nitroimidazolyl) alkanecarboxamides: a new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitizers
MP Hay, WR Wilson, JW Moselen, BD Palmer, WA Denny
Journal of medicinal chemistry 37 (3), 381-391, 1994
DNA-targeted 1, 2, 4-benzotriazine 1, 4-dioxides: potent analogues of the hypoxia-selective cytotoxin tirapazamine
MP Hay, FB Pruijn, SA Gamage, HDS Liyanage, MS Kovacs, ...
Journal of medicinal chemistry 47 (2), 475-488, 2004
Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapy
MP Hay, RF Anderson, DM Ferry, WR Wilson, WA Denny
Journal of medicinal chemistry 46 (25), 5533-5545, 2003
Tricyclic [1, 2, 4] triazine 1, 4-dioxides as hypoxia selective cytotoxins
MP Hay, KO Hicks, K Pchalek, HH Lee, A Blaser, FB Pruijn, RF Anderson, ...
Journal of medicinal chemistry 51 (21), 6853-6865, 2008
Selective reaction of glycine residues in hydrogen atom transfer from amino acid derivatives
VA Burgess, CJ Easton, MP Hay
Journal of the American Chemical Society 111 (3), 1047-1052, 1989
A 2-nitroimidazole carbamate prodrug of 5-amino-1-(chloromethyl)-3-[(5, 6, 7-trimethoxyindol-2-yl) carbonyl]-1, 2-dihydro-3H-benz [e] indole (amino-seco-CBI-TMI) for use with …
MP Hay, BM Sykes, WA Denny, WR Wilson
Bioorganic & medicinal chemistry letters 9 (15), 2237-2242, 1999
4-Pyridylanilinothiazoles that selectively target von Hippel− Lindau deficient renal cell carcinoma cells by inducing autophagic cell death
MP Hay, S Turcotte, JU Flanagan, M Bonnet, DA Chan, PD Sutphin, ...
Journal of medicinal chemistry 53 (2), 787-797, 2010
The 2-Nitroimidazole EF5 Is a Biomarker for Oxidoreductases That Activate the Bioreductive Prodrug CEN-209 under HypoxiaA Predictive Biomarker for Hypoxia-Activated Prodrug CEN-209
J Wang, A Foehrenbacher, J Su, R Patel, MP Hay, KO Hicks, WR Wilson
Clinical Cancer Research 18 (6), 1684-1695, 2012
Design, synthesis and evaluation of imidazolylmethyl carbamate prodrugs of alkylating agents
MP Hay, WR Wilson, WA Denny
Tetrahedron 56 (4), 645-657, 2000
Substituent effects on the kinetics of reductively-initiated fragmentation of nitrobenzyl carbamates designed as triggers for bioreductive prodrugs
MP Hay, BM Sykes, WA Denny, CJ O’Connor
Journal of the Chemical Society, Perkin Transactions 1, 2759-2770, 1999
Spin Trapping of Radicals Other Than the OH Radical upon Reduction of the Anticancer Agent Tirapazamine by Cytochrome P450 Reductase
SS Shinde, MP Hay, AV Patterson, WA Denny, RF Anderson
Journal of the American Chemical Society 131 (40), 14220-14221, 2009
Extravascular transport of drugs in tumor tissue: effect of lipophilicity on diffusion of tirapazamine analogues in multicellular layer cultures
FB Pruijn, JR Sturman, HDS Liyanage, KO Hicks, MP Hay, WR Wilson
Journal of medicinal chemistry 48 (4), 1079-1087, 2005
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