David Hugh Williams
David Hugh Williams
CEO Sulantrix
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Cited by
Cited by
ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis
P Towler, B Staker, SG Prasad, S Menon, J Tang, T Parsons, D Ryan, ...
Journal of Biological Chemistry 279 (17), 17996-18007, 2004
Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function
JB Wardenburg, C Fu, JK Jackman, H Flotow, SE Wilkinson, DH Williams, ...
Journal of Biological Chemistry 271 (33), 19641-19644, 1996
Iminosugars past, present and future: medicines for tomorrow
G Horne, FX Wilson, J Tinsley, DH Williams, R Storer
Drug discovery today 16 (3-4), 107-118, 2011
Structure of the catalytic domain of human fibroblast collagenase complexed with an inhibitor
N Borkakoti, FK Winkler, DH Williams, A D'arcy, MJ Broadhurst, RA Brown, ...
Nature structural biology 1 (2), 106-110, 1994
Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine
MBAC Lamers, AA Antson, RE Hubbard, RK Scott, DH Williams
Journal of molecular biology 285 (2), 713-725, 1999
Recent kinase and kinase inhibitor X-ray structures: mechanisms of inhibition and selectivity insights
M Cherry, DH Williams
Current medicinal chemistry 11 (6), 663-673, 2004
Drug-resistant aurora A mutants for cellular target validation of the small molecule kinase inhibitors MLN8054 and MLN8237
DA Sloane, MZ Trikic, MLH Chu, MBAC Lamers, CS Mason, I Mueller, ...
ACS chemical biology 5 (6), 563-576, 2010
The Preclinical Pharmacology and Therapeutic Activity of the Novel CHK1 Inhibitor SAR-020106Preclinical Pharmacology of CHK1 Inhibitor SAR-020106
MI Walton, PD Eve, A Hayes, M Valenti, A De Haven Brandon, G Box, ...
Molecular cancer therapeutics 9 (1), 89-100, 2010
Discovery and exploitation of inhibitor-resistant aurora and polo kinase mutants for the analysis of mitotic networks
PJ Scutt, MLH Chu, DA Sloane, M Cherry, CR Bignell, DH Williams, ...
Journal of Biological Chemistry 284 (23), 15880-15893, 2009
Ro 09-2210 exhibits potent anti-proliferative effects on activated T cells by selectively blocking MKK activity
DH Williams, SE Wilkinson, T Purton, A Lamont, H Flotow, EJ Murray
Biochemistry 37 (26), 9579-9585, 1998
Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing
JC Reader, TP Matthews, S Klair, KMJ Cheung, J Scanlon, N Proisy, ...
Journal of medicinal chemistry 54 (24), 8328-8342, 2011
The role of protein kinase C in the regulation of extracellular signal‐regulated kinase by the T cell antigen receptor
M Izquierdo, SJ Leevers, DH Williams, CJ Marshall, A Weiss, D Cantrell
European journal of immunology 24 (10), 2462-2468, 1994
Structure of a Cys25→ Ser mutant of human cathepsin S
JP Turkenburg, MBAC Lamers, AM Brzozowski, LM Wright, RE Hubbard, ...
Acta Crystallographica Section D: Biological Crystallography 58 (3), 451-455, 2002
Identification of inhibitors of checkpoint kinase 1 through template screening
TP Matthews, S Klair, S Burns, K Boxall, M Cherry, M Fisher, IM Westwood, ...
Journal of medicinal chemistry 52 (15), 4810-4819, 2009
Protein kinase C is not a downstream effector of p21ras in activated T cells
DH Williams, M Woodrow, DA Cantrell, EJ Murray
European journal of immunology 25 (1), 42-47, 1995
Latest developments in crystallography and structure-based design of protein kinase inhibitors as drug candidates
DH Williams, T Mitchell
Current opinion in pharmacology 2 (5), 567-573, 2002
Biophysical and X-ray Crystallographic Analysis of Mps1 Kinase Inhibitor Complexes,
MLH Chu, Z Lang, LMG Chavas, J Neres, OS Fedorova, L Tabernero, ...
Biochemistry 49 (8), 1689-1701, 2010
Aurothioglucose inhibits induced NF-kB and AP-1 activity by acting as an IL-1 functional antagonist
DH Williams, LJ Jeffery, EJ Murray
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1180 (1), 9-14, 1992
A new regulatory switch in a JAK protein kinase
V Tsui, P Gibbons, M Ultsch, K Mortara, C Chang, W Blair, R Pulk, ...
Proteins: Structure, Function, and Bioinformatics 79 (2), 393-401, 2011
Human MAFA has alternatively spliced variants
MBAC Lamers, AG Lamont, DH Williams
Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression 1399 (2-3 …, 1998
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