Sean Devenish
Sean Devenish
Verified email at cam.ac.uk
Title
Cited by
Cited by
Year
Microfluidic droplets: new integrated workflows for biological experiments
B Kintses, LD van Vliet, SRA Devenish, F Hollfelder
Current opinion in chemical biology 14 (5), 548-555, 2010
1972010
One in a Million: Flow Cytometric Sorting of Single Cell-Lysate Assays in Monodisperse Picolitre Double Emulsion Droplets for Directed Evolution
A Zinchenko, SRA Devenish, B Kintses, PY Colin, M Fischlechner, ...
Analytical chemistry 86 (5), 2526-2533, 2014
1572014
A Fully Unsupervised Compartment-on-Demand Platform for Precise Nanoliter Assays of Time-Dependent Steady-State Enzyme Kinetics and Inhibition
F Gielen, L van Vliet, BT Koprowski, SRA Devenish, M Fischlechner, ...
Analytical chemistry 85 (9), 4761-4769, 2013
812013
Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis
G Kefala, GL Evans, MDW Griffin, SRA Devenish, FG Pearce, MA Perugini, ...
Biochemical Journal 411 (2), 351-360, 2008
782008
Role of arginine 138 in the catalysis and regulation of Escherichia coli dihydrodipicolinate synthase
RCJ Dobson, SRA Devenish, LA Turner, VR Clifford, FG Pearce, ...
Biochemistry 44 (39), 13007-13013, 2005
532005
Inhibiting dihydrodipicolinate synthase across species: Towards specificity for pathogens?
V Mitsakos, RCJ Dobson, FG Pearce, SR Devenish, GL Evans, ...
Bioorganic & medicinal chemistry letters 18 (2), 842-844, 2008
452008
Dual side-reactions limit the utility of a key polymer therapeutic precursor
SRA Devenish, JB Hill, JW Blunt, JC Morris, MHG Munro
Tetrahedron letters 47 (17), 2875-2878, 2006
392006
On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products
KL Saar, Y Zhang, T Müller, CP Kumar, S Devenish, A Lynn, U Łapińska, ...
Lab on a Chip 18 (1), 162-170, 2018
352018
How essential is the ‘essential’active-site lysine in dihydrodipicolinate synthase?
TPS da Costa, AC Muscroft-Taylor, RCJ Dobson, SRA Devenish, ...
Biochimie 92 (7), 837-845, 2010
352010
Cloning and characterisation of dihydrodipicolinate synthase from the pathogen Neisseria meningitidis
SRA Devenish, FHA Huisman, EJ Parker, AT Hadfield, JA Gerrard
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1794 (8), 1168-1174, 2009
342009
Conserved main‐chain peptide distortions: A proposed role for Ile203 in catalysis by dihydrodipicolinate synthase
RCJ Dobson, MDW Griffin, SRA Devenish, FG Pearce, CA Hutton, ...
Protein Science 17 (12), 2080-2090, 2008
332008
A single mutation in the core domain of the lac repressor reduces leakiness
P Gatti-Lafranconi, WP Dijkman, SRA Devenish, F Hollfelder
Microb. Cell Fact 12 (67.10), 1186, 2013
322013
A simple method to evaluate the biochemical compatibility of oil/surfactant mixtures for experiments in microdroplets
M Kaltenbach, SRA Devenish, F Hollfelder
Lab on a Chip 12 (20), 4185-4192, 2012
322012
Characterisation of dihydrodipicolinate synthase (DHDPS) from Bacillus anthracis
LJ Domigan, SW Scally, MJ Fogg, CA Hutton, MA Perugini, RCJ Dobson, ...
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1794 (10), 1510-1516, 2009
322009
The role of quaternary structure in (β/α) 8-barrel proteins: evolutionary happenstance or a higher level of structure-function relationships?
SRA Devenish, JA Gerrard
Organic & biomolecular chemistry 7 (5), 833-839, 2009
292009
Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies
S Linse, T Scheidt, K Bernfur, M Vendruscolo, CM Dobson, SIA Cohen, ...
Nature Structural & Molecular Biology 27 (12), 1125-1133, 2020
282020
The high-resolution structure of dihydrodipicolinate synthase from Escherichia coli bound to its first substrate, pyruvate
SRA Devenish, JA Gerrard, GB Jameson, RCJ Dobson
Acta Crystallographica Section F: Structural Biology and Crystallization …, 2008
282008
NMR studies uncover alternate substrates for dihydrodipicolinate synthase and suggest that dihydrodipicolinate reductase is also a dehydratase
SRA Devenish, JW Blunt, JA Gerrard
Journal of medicinal chemistry 53 (12), 4808-4812, 2010
272010
A tetrameric structure is not essential for activity in dihydrodipicolinate synthase (DHDPS) from Mycobacterium tuberculosis
G Evans, L Schuldt, MDW Griffin, SRA Devenish, FG Pearce, MA Perugini, ...
Archives of biochemistry and biophysics 512 (2), 154-159, 2011
162011
Accessing unexplored regions of sequence space in directed enzyme evolution via insertion/deletion mutagenesis
S Emond, M Petek, EJ Kay, B Heames, SRA Devenish, N Tokuriki, ...
Nature communications 11 (1), 1-14, 2020
152020
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Articles 1–20