Ruben van Boxtel
Ruben van Boxtel
Principal Investigator
Verified email at - Homepage
Cited by
Cited by
Organoid models of human and mouse ductal pancreatic cancer
SF Boj, CI Hwang, LA Baker, IIC Chio, DD Engle, V Corbo, M Jager, ...
Cell 160 (1), 324-338, 2015
A living biobank of breast cancer organoids captures disease heterogeneity
N Sachs, J De Ligt, O Kopper, E Gogola, G Bounova, F Weeber, ...
Cell 172 (1), 373-386. e10, 2018
Long-term culture of genome-stable bipotent stem cells from adult human liver
M Huch, H Gehart, R Van Boxtel, K Hamer, F Blokzijl, MMA Verstegen, ...
Cell 160 (1), 299-312, 2015
Sequential cancer mutations in cultured human intestinal stem cells
J Drost, RH Van Jaarsveld, B Ponsioen, C Zimberlin, R Van Boxtel, ...
Nature 521 (7550), 43-47, 2015
Tissue-specific mutation accumulation in human adult stem cells during life
F Blokzijl, J De Ligt, M Jager, V Sasselli, S Roerink, N Sasaki, M Huch, ...
Nature 538 (7624), 260-264, 2016
Mutational signature in colorectal cancer caused by genotoxic pks+E. coli
C Pleguezuelos-Manzano, J Puschhof, A Rosendahl Huber, A van Hoeck, ...
Nature 580 (7802), 269-273, 2020
Identification of multipotent luminal progenitor cells in human prostate organoid cultures
WR Karthaus, PJ Iaquinta, J Drost, A Gracanin, R Van Boxtel, J Wongvipat, ...
Cell 159 (1), 163-175, 2014
MutationalPatterns: comprehensive genome-wide analysis of mutational processes
F Blokzijl, R Janssen, R Van Boxtel, E Cuppen
Genome medicine 10, 1-11, 2018
Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer
J Drost, R Van Boxtel, F Blokzijl, T Mizutani, N Sasaki, V Sasselli, J de Ligt, ...
Science 358 (6360), 234-238, 2017
Genome sequencing of normal cells reveals developmental lineages and mutational processes
S Behjati, M Huch, R Van Boxtel, W Karthaus, DC Wedge, AU Tamuri, ...
Nature 513 (7518), 422-425, 2014
Tubuloids derived from human adult kidney and urine for personalized disease modeling
F Schutgens, MB Rookmaaker, T Margaritis, A Rios, C Ammerlaan, ...
Nature biotechnology 37 (3), 303-313, 2019
Oral mucosal organoids as a potential platform for personalized cancer therapy
E Driehuis, S Kolders, S Spelier, K Lõhmussaar, SM Willems, LA Devriese, ...
Cancer discovery 9 (7), 852-871, 2019
Modulation of glutamine metabolism by the PI (3) K–PKB–FOXO network regulates autophagy
KE Van Der Vos, P Eliasson, T Proikas-Cezanne, SJ Vervoort, ...
Nature cell biology 14 (8), 829-837, 2012
In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels
T Rothgangl, MK Dennis, PJC Lin, R Oka, D Witzigmann, L Villiger, W Qi, ...
Nature biotechnology 39 (8), 949-957, 2021
Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids
A Fumagalli, J Drost, SJE Suijkerbuijk, R Van Boxtel, J De Ligt, ...
Proceedings of the National Academy of Sciences 114 (12), E2357-E2364, 2017
The mutational landscape of human somatic and germline cells
L Moore, A Cagan, THH Coorens, MDC Neville, R Sanghvi, MA Sanders, ...
Nature 597 (7876), 381-386, 2021
The role of SRY-related HMG box transcription factor 4 (SOX4) in tumorigenesis and metastasis: friend or foe?
SJ Vervoort, R van Boxtel, PJ Coffer
Oncogene 32 (29), 3397-3409, 2013
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity
C Calandrini, F Schutgens, R Oka, T Margaritis, T Candelli, L Mathijsen, ...
Nature communications 11 (1), 1310, 2020
Canonical Wnt signaling negatively modulates regulatory T cell function
J Van Loosdregt, V Fleskens, MM Tiemessen, M Mokry, R van Boxtel, ...
Immunity 39 (2), 298-310, 2013
Somatic mutations reveal lineage relationships and age-related mutagenesis in human hematopoiesis
FG Osorio, AR Huber, R Oka, M Verheul, SH Patel, K Hasaart, ...
Cell reports 25 (9), 2308-2316. e4, 2018
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