Genetically encoded fragment-based discovery from phage-displayed macrocyclic libraries with genetically encoded unnatural pharmacophores AI Ekanayake, L Sobze, P Kelich, J Youk, NJ Bennett, R Mukherjee, ... Journal of the American Chemical Society 143 (14), 5497-5507, 2021 | 46 | 2021 |
A chemical-genetic approach to generate selective covalent inhibitors of protein kinases A Kung, M Schimpl, A Ekanayake, YC Chen, R Overman, C Zhang ACS chemical biology 12 (6), 1499-1503, 2017 | 25 | 2017 |
Targeting CTP synthetase 1 to restore interferon induction and impede nucleotide synthesis in SARS-CoV-2 infection Y Rao, TY Wang, C Qin, B Espinosa, Q Liu, A Ekanayake, J Zhao, ... BioRxiv, 2021 | 13 | 2021 |
Synthesis and target identification of a novel electrophilic warhead, 2-chloromethylquinoline F Ni, A Ekanayake, B Espinosa, C Yu, JN Sanders, J Perino, KN Houk, ... Biochemistry 58 (24), 2715-2719, 2019 | 10 | 2019 |
Genetically encoded fragment-based discovery (GE-FBD) from phage-displayed macrocyclic libraries with genetically-encoded unnatural pharmacophores A Ekanayake, L Sobze, J Youk, NJ Bennett, R Mukherjee, A Bhardwaj, ... | 3 | 2020 |
Genetically encoded discovery of perfluoroaryl macrocycles that bind to albumin and exhibit extended circulation in vivo JYK Wong, AI Ekanayake, S Kharchenko, SE Kirberger, R Qiu, P Kelich, ... Nature communications 14 (1), 5654, 2023 | 1 | 2023 |
Late-stage reshaping of phage-displayed libraries to macrocyclic and bicyclic landscapes using multipurpose linchpin K Yan, M Miskolzie, FB Mejia, C Peng, AI Ekanayake, DJ Maly, R Derda | | 2024 |
Late-stage reshaping of phage-displayed libraries to macrocyclic and bicyclic landscapes using multipurpose linchpin R Derda, K Yan, M Miskolzie, FB Mejia, DJ Maly, AI Ekanayake, C Peng | | 2024 |
Identification of Covalent Ligands – from Single Targets to Whole Proteome PCZ Chau Ngo, Dr. Arunika Ekanayake Israel Journal of Chemistry, e202200105, 2023 | | 2023 |
Targeting CTP Synthetase 1 to Restore Interferon Induction and Impede Nucleotide Synthesis in SARS-CoV-2 Infection (preprint) Y Rao, TY Wang, C Qin, B Espinosa, Q Liu, A Ekanayake, J Zhao, ... | | 2021 |
GENETICALLY-ENCODED MACROCYCLIC PEPTIDE LIBRARIES BEARING A PHARMACOPHORE R DERDA, A MUKHERJEE, RAJA, EKANAYAKE WO Patent WO/2020/107,118, 2020 | | 2020 |
NOVEL INHIBITORS OF GUANOSINE MONOPHOSPHATE SYNTHETASE AS THERAPEUTIC AGENTS C ZHANG, F NI, A EKANAYAKE, B ESPINOSA WO Patent WO/2020/055,504, 2020 | | 2020 |
Chemoproteomic approach for discovering covalent ligands for diverse protein targets C Zhang, F Ni, AI Ekanayake US Patent App. 16/339,621, 2020 | | 2020 |
Exploration of target space of electrophilic quinazolines B Espinosa, A Ekanayake, C Zhang ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 258, 2019 | | 2019 |