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Samuel Goodchild
Samuel Goodchild
Xenon Pharmaceuticals
Verified email at xenon-pharma.com
Title
Cited by
Cited by
Year
Inhibitory effects of cannabidiol on voltage-dependent sodium currents
MR Ghovanloo, NG Shuart, J Mezeyova, RA Dean, PC Ruben, ...
Journal of Biological Chemistry 293 (43), 16546-16558, 2018
1712018
Allosteric block of KCa2 channels by apamin
C Lamy, SJ Goodchild, KL Weatherall, DE Jane, JF Liégeois, V Seutin, ...
Journal of Biological Chemistry 285 (35), 27067-27077, 2010
1102010
Small conductance calcium-activated potassium channels: from structure to function
KL Weatherall, SJ Goodchild, DE Jane, NV Marrion
Progress in neurobiology 91 (3), 242-255, 2010
992010
Local anesthetic inhibition of a bacterial sodium channel
S Lee, SJ Goodchild, CA Ahern
Journal of General Physiology 139 (6), 507-516, 2012
702012
Selective NaV1. 7 antagonists with long residence time show improved efficacy against inflammatory and neuropathic pain
G Bankar, SJ Goodchild, S Howard, K Nelkenbrecher, M Waldbrook, ...
Cell reports 24 (12), 3133-3145, 2018
532018
Cannabidiol inhibits the skeletal muscle Nav1. 4 by blocking its pore and by altering membrane elasticity
MR Ghovanloo, K Choudhury, TS Bandaru, MA Fouda, K Rayani, ...
Journal of General Physiology 153 (5), e202012701, 2021
452021
Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3-a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNa …
T Focken, S Chowdhury, A Zenova, ME Grimwood, C Chabot, T Sheng, ...
Journal of medicinal chemistry 61 (11), 4810-4831, 2018
312018
NBI-921352, a first-in-class, NaV1. 6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats
JP Johnson, T Focken, K Khakh, PK Tari, C Dube, SJ Goodchild, ...
Elife 11, e72468, 2022
282022
Sequence of gating charge movement and pore gating in HERG activation and deactivation pathways
SJ Goodchild, LC Macdonald, D Fedida
Biophysical journal 108 (6), 1435-1447, 2015
282015
Components of gating charge movement and S4 voltage-sensor exposure during activation of hERG channels
Z Wang, Y Dou, SJ Goodchild, Z Es-Salah-Lamoureux, D Fedida
Journal of General Physiology 141 (4), 431-443, 2013
282013
Tris-pyrazolylborate complexes of redox inactive lanthanides–the structures of [(TpMe2) 2NdX](X= Cl, NPh2, dpm, H2BEt2)
JL Galler, S Goodchild, J Gould, R McDonald, A Sella
Polyhedron 23 (2-3), 253-262, 2004
242004
Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy
T Focken, K Burford, ME Grimwood, A Zenova, JC Andrez, W Gong, ...
Journal of medicinal chemistry 62 (21), 9618-9641, 2019
222019
Gating charge movement precedes ionic current activation in hERG channels
SJ Goodchild, D Fedida
Channels 8 (1), 84-89, 2014
222014
Inhibition of KCa2.2 and KCa2.3 channel currents by protonation of outer pore histidine residues
SJ Goodchild, C Lamy, V Seutin, NV Marrion
Journal of General Physiology 134 (4), 295-308, 2009
182009
Molecular and functional determinants of local anesthetic inhibition of NaChBac
S Lee, SJ Goodchild, CA Ahern
Channels 6 (5), 403-406, 2012
172012
Basis for allosteric open-state stabilization of voltage-gated potassium channels by intracellular cations
SJ Goodchild, H Xu, Z Es-Salah-Lamoureux, CA Ahern, D Fedida
Journal of General Physiology 140 (5), 495-511, 2012
162012
Blockade of permeation by potassium but normal gating of the G628S nonconducting hERG channel mutant
Z Es-Salah-Lamoureux, PY Xiong, SJ Goodchild, CA Ahern, D Fedida
Biophysical journal 101 (3), 662-670, 2011
132011
Contributions of intracellular ions to Kv channel voltage sensor dynamics
SJ Goodchild, D Fedida
Frontiers in Pharmacology 3, 114, 2012
92012
The neutral, hydrophobic isoleucine at position I521 in the extracellular S4 domain of hERG contributes to channel gating equilibrium
Y Dou, SJ Goodchild, RV Velde, Y Wu, D Fedida
American Journal of Physiology-Cell Physiology 305 (4), C468-C478, 2013
82013
Cannabidiol increases gramicidin current in human embryonic kidney cells: An observational study
MR Ghovanloo, SJ Goodchild, PC Ruben
Plos one 17 (8), e0271801, 2022
72022
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