| TDP-43 triggers mitochondrial DNA release via mPTP to activate cGAS/STING in ALS CH Yu, S Davidson, CR Harapas, JB Hilton, MJ Mlodzianoski, ... Cell 183 (3), 636-649. e18, 2020 | 621 | 2020 |
| Tau-mediated iron export prevents ferroptotic damage after ischemic stroke QZ Tuo, P Lei, KA Jackman, XL Li, H Xiong, ZY Liuyang, L Roisman, ... Molecular psychiatry 22 (11), 1520-1530, 2017 | 589 | 2017 |
| Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-β1-42 PJ Crouch, R Blake, JA Duce, GD Ciccotosto, QX Li, KJ Barnham, ... Journal of Neuroscience 25 (3), 672-679, 2005 | 399 | 2005 |
| Mechanisms of Aβ mediated neurodegeneration in Alzheimer's disease PJ Crouch, SME Harding, AR White, J Camakaris, AI Bush, CL Masters The international journal of biochemistry & cell biology 40 (2), 181-198, 2008 | 322 | 2008 |
| Increasing Cu bioavailability inhibits Aβ oligomers and tau phosphorylation PJ Crouch, LW Hung, PA Adlard, M Cortes, V Lal, G Filiz, KA Perez, ... Proceedings of the National Academy of Sciences 106 (2), 381-386, 2009 | 315 | 2009 |
| The Alzheimer’s therapeutic PBT2 promotes amyloid‐β degradation and GSK3 phosphorylation via a metal chaperone activity PJ Crouch, MS Savva, LW Hung, PS Donnelly, AI Mot, SJ Parker, ... Journal of neurochemistry 119 (1), 220-230, 2011 | 232 | 2011 |
| ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation AK Walker, KY Soo, V Sundaramoorthy, S Parakh, Y Ma, MA Farg, ... PloS one 8 (11), e81170, 2013 | 201 | 2013 |
| Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates SJ Parker, J Meyerowitz, JL James, JR Liddell, PJ Crouch, KM Kanninen, ... Neurochemistry international 60 (4), 415-424, 2012 | 192 | 2012 |
| The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson’s disease LW Hung, VL Villemagne, L Cheng, NA Sherratt, S Ayton, AR White, ... Journal of Experimental Medicine 209 (4), 837-854, 2012 | 188 | 2012 |
| Oral treatment with CuII (atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis BR Roberts, NKH Lim, EJ McAllum, PS Donnelly, DJ Hare, PA Doble, ... Journal of Neuroscience 34 (23), 8021-8031, 2014 | 183 | 2014 |
| Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SODG93A mice co-expressing the Copper-Chaperone-for-SOD JR Williams, E Trias, PR Beilby, NI Lopez, EM Labut, CS Bradford, ... Neurobiology of disease 89, 1-9, 2016 | 160 | 2016 |
| Diacetylbis (N (4)-methylthiosemicarbazonato) copper (II)(CuII (atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral … CPW Soon, PS Donnelly, BJ Turner, LW Hung, PJ Crouch, NA Sherratt, ... Journal of Biological Chemistry 286 (51), 44035-44044, 2011 | 150 | 2011 |
| Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease PA Adlard, L Bica, AR White, M Nurjono, G Filiz, PJ Crouch, PS Donnelly, ... PloS one 6 (3), e17669, 2011 | 149 | 2011 |
| Therapeutic redistribution of metal ions to treat Alzheimer’s disease PJ Crouch, KJ Barnham Accounts of chemical research 45 (9), 1604-1611, 2012 | 144 | 2012 |
| C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress J Meyerowitz, SJ Parker, LJ Vella, DCH Ng, KA Price, JR Liddell, ... Molecular neurodegeneration 6, 1-22, 2011 | 144 | 2011 |
| Superoxide dismutase 1 in health and disease: how a frontline antioxidant becomes neurotoxic BG Trist, JB Hilton, DJ Hare, PJ Crouch, KL Double Angewandte Chemie International Edition 60 (17), 9215-9246, 2021 | 127 | 2021 |
| An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis (4-methylthiosemicarbazonato) copperII PS Donnelly, JR Liddell, SC Lim, BM Paterson, MA Cater, MS Savva, ... Proceedings of the National Academy of Sciences 109 (1), 47-52, 2012 | 123 | 2012 |
| CuII(atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease A Southon, K Szostak, KM Acevedo, KA Dent, I Volitakis, AA Belaidi, ... British journal of pharmacology 177 (3), 656-667, 2020 | 116 | 2020 |
| Restored degradation of the Alzheimer’s amyloid‐β peptide by targeting amyloid formation PJ Crouch, DJ Tew, T Du, DN Nguyen, A Caragounis, G Filiz, RE Blake, ... Journal of neurochemistry 108 (5), 1198-1207, 2009 | 109 | 2009 |
| The modulation of metal bio‐availability as a therapeutic strategy for the treatment of Alzheimer's disease PJ Crouch, AR White, AI Bush The FEBS journal 274 (15), 3775-3783, 2007 | 97 | 2007 |
