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Joshua Pajak
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A viral genome packaging motor transitions between cyclic and helical symmetry to translocate dsDNA
M Woodson, J Pajak, BP Mahler, W Zhao, W Zhang, G Arya, MA White, ...
Science Advances 7 (19), eabc1955, 2021
462021
Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader
C Gaubitz, X Liu, J Pajak, NP Stone, JA Hayes, G Demo, BA Kelch
Elife 11, e74175, 2022
352022
Redox-sensitive E2 Rad6 controls cellular response to oxidative stress via K63-linked ubiquitination of ribosomes
V Simões, BK Cizubu, L Harley, Y Zhou, J Pajak, NA Snyder, J Bouvette, ...
Cell reports 39 (8), 2022
222022
Atomistic basis of force generation, translocation, and coordination in a viral genome packaging motor
J Pajak, E Dill, E Reyes-Aldrete, MA White, BA Kelch, PJ Jardine, G Arya, ...
Nucleic acids research 49 (11), 6474-6488, 2021
202021
Functional dissection of a viral DNA packaging Machine's Walker B Motif
D Ortiz, M Ordyan, J Pajak, J Sippy, A Catala, CS Oh, A Vu, G Arya, ...
Journal of molecular biology 431 (22), 4455-4474, 2019
172019
Evidence that a catalytic glutamate and an ‘Arginine Toggle’ act in concert to mediate ATP hydrolysis and mechanochemical coupling in a viral DNA packaging motor
D Ortiz, D delToro, M Ordyan, J Pajak, J Sippy, A Catala, CS Oh, A Vu, ...
Nucleic acids research 47 (3), 1404-1415, 2018
172018
Interaction of PCL based self-assembled nano-polymeric micelles with model lipid bilayers using coarse-grained molecular dynamics simulations
AS Raman, J Pajak, YC Chiew
Chemical physics letters 712, 1-6, 2018
162018
Viral packaging ATPases utilize a glutamate switch to couple ATPase activity and DNA translocation
J Pajak, R Atz, BJ Hilbert, MC Morais, BA Kelch, PJ Jardine, G Arya
Proceedings of the National Academy of Sciences 118 (17), e2024928118, 2021
142021
A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA
X Liu, C Gaubitz, J Pajak, BA Kelch
Elife 11, e77483, 2022
92022
Biophysics of DNA packaging
J Pajak, G Arya, DE Smith
Academic Press, 2021
62021
Conformational dynamics control assembly of an extremely long bacteriophage tail tube
E Agnello, J Pajak, X Liu, BA Kelch
Journal of Biological Chemistry 299 (3), 2023
52023
Molecular dynamics of DNA translocation by FtsK
J Pajak, G Arya
Nucleic Acids Research 50 (15), 8459-8470, 2022
32022
The mechano-chemistry of a viral genome packaging motor
J Pajak, NS Prokhorov, PJ Jardine, MC Morais
Current Opinion in Structural Biology 89, 102945, 2024
12024
Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication
JT Landeck, J Pajak, EK Norman, EL Sedivy, BA Kelch
Journal of Biological Chemistry 300 (4), 2024
12024
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