Normalization strategies for metabonomic analysis of urine samples BM Warrack, S Hnatyshyn, KH Ott, MD Reily, M Sanders, H Zhang, ... Journal of Chromatography B 877 (5-6), 547-552, 2009 | 359 | 2009 |
Utility of imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization (MALDI) on an ion trap mass spectrometer in the analysis of drugs and metabolites in … DM Drexler, TJ Garrett, JL Cantone, RW Diters, JG Mitroka, ... Journal of pharmacological and toxicological methods 55 (3), 279-288, 2007 | 142 | 2007 |
An empirical process for the design of high-throughput screening deck filters BC Pearce, MJ Sofia, AC Good, DM Drexler, DA Stock Journal of chemical information and modeling 46 (3), 1060-1068, 2006 | 112 | 2006 |
An automated liquid chromatography-mass spectrometry process to determine metabolic stability half-life and intrinsic clearance of drug candidates by substrate depletion CA McNaney, DM Drexler, SY Hnatyshyn, TA Zvyaga, JO Knipe, ... Assay and drug development technologies 6 (1), 121-129, 2008 | 103 | 2008 |
Nocathiacins, new thiazolyl peptide antibiotics from Nocardia sp. II. Isolation, characterization, and structure determination JE Leet, W Li, HA Ax, JA Matson, S Huang, R Huang, JL Cantone, ... The Journal of Antibiotics 56 (3), 232-242, 2003 | 102 | 2003 |
Comparative evaluation of plasma bile acids, dehydroepiandrosterone sulfate, hexadecanedioate, and tetradecanedioate with coproporphyrins I and III as markers of OATP … H Shen, W Chen, DM Drexler, S Mandlekar, VK Holenarsipur, EE Shields, ... Drug Metabolism and Disposition 45 (8), 908-919, 2017 | 81 | 2017 |
Advances in mass spectrometry applied to pharmaceutical metabolomics DM Drexler, MD Reily, PA Shipkova Analytical and bioanalytical chemistry 399, 2645-2653, 2011 | 81 | 2011 |
The amyloid-β rise and γ-secretase inhibitor potency depend on the level of substrate expression CR Burton, JE Meredith, DM Barten, ME Goldstein, CM Krause, CJ Kieras, ... Journal of Biological Chemistry 283 (34), 22992-23003, 2008 | 78 | 2008 |
Extraction, identification, and functional characterization of a bioactive substance from automated compound-handling plastic tips J Watson, EB Greenough, JE Leet, MJ Ford, DM Drexler, JV Belcastro, ... SLAS Discovery 14 (5), 566-572, 2009 | 58 | 2009 |
P-glycoprotein efflux and other factors limit brain amyloid β reduction by β-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice JE Meredith, LA Thompson, JH Toyn, L Marcin, DM Barten, ... Journal of Pharmacology and Experimental Therapeutics 326 (2), 502-513, 2008 | 54 | 2008 |
A high‐throughput bioanalytical platform using automated infusion for tandem mass spectrometric method optimization and its application in a metabolic stability screen K Kieltyka, J Zhang, S Li, M Vath, C Baglieri, C Ferraro, TA Zvyaga, ... Rapid Communications in Mass Spectrometry: An International Journal Devoted …, 2009 | 46 | 2009 |
The γ-secretase modulator, BMS-932481, modulates Aβ peptides in the plasma and cerebrospinal fluid of healthy volunteers HD Soares, M Gasior, JH Toyn, JS Wang, Q Hong, F Berisha, MT Furlong, ... Journal of Pharmacology and Experimental Therapeutics 358 (1), 138-150, 2016 | 45 | 2016 |
Application of ion trap technology to liquid chromatography/mass spectrometry quantitation of large peptides P Shipkova, DM Drexler, R Langish, J Smalley, ME Salyan, M Sanders Rapid Communications in Mass Spectrometry: An International Journal Devoted …, 2008 | 43 | 2008 |
Evidence for the validity of pyridoxic acid (PDA) as a plasma-based endogenous probe for OAT1 and OAT3 function in healthy subjects H Shen, VK Holenarsipur, TT Mariappan, DM Drexler, JL Cantone, ... Journal of Pharmacology and Experimental Therapeutics 368 (1), 136-145, 2019 | 42 | 2019 |
Utility of quantitative whole-body autoradiography (QWBA) and imaging mass spectrometry (IMS) by matrix-assisted laser desorption/ionization (MALDI) in the assessment of ocular … DM Drexler, SH Tannehill-Gregg, L Wang, BJ Brock Journal of pharmacological and toxicological methods 63 (2), 205-208, 2011 | 42 | 2011 |
2016 White Paper on recent issues in bioanalysis: focus on biomarker assay validation (BAV)(Part 1–small molecules, peptides and small molecule biomarkers by LCMS) E Yang, J Welink, S Cape, E Woolf, J Sydor, C James, D Goykhman, ... Bioanalysis 8 (22), 2363-2378, 2016 | 40 | 2016 |
An automated high throughput liquid chromatography–mass spectrometry process to assess the metabolic stability of drug candidates DM Drexler, JV Belcastro, KE Dickinson, KJ Edinger, SY Hnatyshyn, ... Assay and Drug Development Technologies 5 (2), 247-264, 2007 | 34 | 2007 |
Qualitative and quantitative characterization of the amyloid β peptide (Aβ) population in biological matrices using an immunoprecipitation–LC/MS assay MJ Ford, JL Cantone, C Polson, JH Toyn, JE Meredith, DM Drexler Journal of neuroscience methods 168 (2), 465-474, 2008 | 29 | 2008 |
Coupling laser diode thermal desorption with acoustic sample deposition to improve throughput of mass spectrometry–based screening Z Haarhoff, A Wagner, P Picard, DM Drexler, T Zvyaga, W Shou Journal of Biomolecular Screening 21 (2), 165-175, 2016 | 26 | 2016 |
Strategy to improve the quantitative LC-MS analysis of molecular ions resistant to gas-phase collision induced dissociation: application to disulfide-rich cyclic peptides E Ciccimaro, A Ranasinghe, C D’Arienzo, C Xu, J Onorato, DM Drexler, ... Analytical chemistry 86 (23), 11523-11527, 2014 | 26 | 2014 |