| Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV A Stukalov, V Girault, V Grass, O Karayel, V Bergant, C Urban, DA Haas, ... Nature 594 (7862), 246-252, 2021 | 580 | 2021 |
| Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death JM Hildebrand, MC Tanzer, IS Lucet, SN Young, SK Spall, P Sharma, ... Proceedings of the National Academy of Sciences 111 (42), 15072-15077, 2014 | 554 | 2014 |
| NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase‐4 and caspase‐5 PJ Baker, D Boucher, D Bierschenk, C Tebartz, PG Whitney, DB D'Silva, ... European journal of immunology 45 (10), 2918-2926, 2015 | 351 | 2015 |
| The pseudokinase MLKL and the kinase RIPK3 have distinct roles in autoimmune disease caused by loss of death-receptor-induced apoptosis S Alvarez-Diaz, CP Dillon, N Lalaoui, MC Tanzer, DA Rodriguez, A Lin, ... Immunity 45 (3), 513-526, 2016 | 212 | 2016 |
| Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis EJ Petrie, JJ Sandow, AV Jacobsen, BJ Smith, MDW Griffin, IS Lucet, ... Nature communications 9 (1), 2422, 2018 | 173 | 2018 |
| The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia G Brumatti, C Ma, N Lalaoui, NY Nguyen, M Navarro, MC Tanzer, ... Science translational medicine 8 (339), 339ra69-339ra69, 2016 | 162 | 2016 |
| HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death AV Jacobsen, KN Lowes, MC Tanzer, IS Lucet, JM Hildebrand, EJ Petrie, ... Cell death & disease 7 (1), e2051-e2051, 2016 | 154 | 2016 |
| Targeting of Fn14 prevents cancer-induced cachexia and prolongs survival AJ Johnston, KT Murphy, L Jenkinson, D Laine, K Emmrich, P Faou, ... Cell 162 (6), 1365-1378, 2015 | 138 | 2015 |
| Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL JM Murphy, IS Lucet, JM Hildebrand, MC Tanzer, SN Young, P Sharma, ... Biochemical Journal 457 (3), 369-377, 2014 | 108 | 2014 |
| The polycomb repressive complex 2 governs life and death of peripheral T cells Y Zhang, S Kinkel, J Maksimovic, E Bandala-Sanchez, MC Tanzer, ... Blood, The Journal of the American Society of Hematology 124 (5), 737-749, 2014 | 107 | 2014 |
| Evolutionary divergence of the necroptosis effector MLKL MC Tanzer, I Matti, JM Hildebrand, SN Young, A Wardak, A Tripaydonis, ... Cell Death & Differentiation 23 (7), 1185-1197, 2016 | 105 | 2016 |
| Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop MC Tanzer, A Tripaydonis, AI Webb, SN Young, LN Varghese, C Hall, ... Biochemical Journal 471 (2), 255-265, 2015 | 104 | 2015 |
| TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1 N Etemadi, M Chopin, H Anderton, MC Tanzer, JA Rickard, W Abeysekera, ... elife 4, e10592, 2015 | 94 | 2015 |
| Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology FM Hansen, MC Tanzer, F Brüning, I Bludau, C Stafford, BA Schulman, ... Nature Communications 12 (1), 254, 2021 | 86 | 2021 |
| The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis KA Davies, MC Tanzer, MDW Griffin, YF Mok, SN Young, R Qin, EJ Petrie, ... Cell Death & Differentiation 25 (9), 1567-1580, 2018 | 79 | 2018 |
| The structural context of posttranslational modifications at a proteome-wide scale I Bludau, S Willems, WF Zeng, MT Strauss, FM Hansen, MC Tanzer, ... PLoS biology 20 (5), e3001636, 2022 | 72 | 2022 |
| A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction JM Hildebrand, M Kauppi, IJ Majewski, Z Liu, AJ Cox, S Miyake, EJ Petrie, ... Nature communications 11 (1), 3150, 2020 | 69 | 2020 |
| Quantitative and dynamic catalogs of proteins released during apoptotic and necroptotic cell death MC Tanzer, A Frauenstein, CA Stafford, K Phulphagar, M Mann, ... Cell reports 30 (4), 1260-1270. e5, 2020 | 59 | 2020 |
| Rapid and in-depth coverage of the (phospho-) proteome with deep libraries and optimal window design for dia-PASEF P Skowronek, M Thielert, E Voytik, MC Tanzer, FM Hansen, S Willems, ... Molecular & Cellular Proteomics 21 (9), 2022 | 58 | 2022 |
| Combination of IAP antagonist and IFNγ activates novel caspase-10-and RIPK1-dependent cell death pathways MC Tanzer, N Khan, JA Rickard, N Etemadi, N Lalaoui, SK Spall, ... Cell Death & Differentiation 24 (3), 481-491, 2017 | 52 | 2017 |
