Michael Farzan
Michael Farzan
Professor of Pediatrics, Harvard Medical School
Verified email at
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Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
W Li, MJ Moore, N Vasilieva, J Sui, SK Wong, MA Berne, ...
Nature 426 (6965), 450-454, 2003
The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
H Choe, M Farzan, Y Sun, N Sullivan, B Rollins, PD Ponath, L Wu, ...
Cell 85 (7), 1135-1148, 1996
The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
CC Bleul, M Farzan, H Choe, C Parolin, I Clark-Lewis, J Sodroski, ...
Nature 382 (6594), 829-833, 1996
Structure of SARS coronavirus spike receptor-binding domain complexed with receptor
F Li, W Li, M Farzan, SC Harrison
Science 309 (5742), 1864-1868, 2005
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
CGK Ziegler, SJ Allon, SK Nyquist, IM Mbano, VN Miao, CN Tzouanas, ...
Cell 181 (5), 1016-1035. e19, 2020
Mechanisms of SARS-CoV-2 entry into cells
CB Jackson, M Farzan, B Chen, H Choe
Nature reviews Molecular cell biology 23 (1), 3-20, 2022
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus
AL Brass, IC Huang, Y Benita, SP John, MN Krishnan, EM Feeley, ...
Cell 139 (7), 1243-1254, 2009
CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia
J He, Y Chen, M Farzan, H Choe, A Ohagen, S Gartner, J Busciglio, ...
Nature 385 (6617), 645-649, 1997
Receptor and viral determinants of SARS‐coronavirus adaptation to human ACE2
W Li, C Zhang, J Sui, JH Kuhn, MJ Moore, S Luo, SK Wong, IC Huang, ...
The EMBO journal 24 (8), 1634-1643, 2005
ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia
HP Jia, DC Look, L Shi, M Hickey, L Pewe, J Netland, M Farzan, ...
Journal of virology 79 (23), 14614-14621, 2005
SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity
L Zhang, CB Jackson, H Mou, A Ojha, H Peng, BD Quinlan, ...
Nature communications 11 (1), 6013, 2020
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I
MU Gack, RA Albrecht, T Urano, KS Inn, IC Huang, E Carnero, M Farzan, ...
Cell host & microbe 5 (5), 439-449, 2009
A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2
SK Wong, W Li, MJ Moore, H Choe, M Farzan
Journal of Biological Chemistry 279 (5), 3197-3201, 2004
The broad-spectrum antiviral functions of IFIT and IFITM proteins
MS Diamond, M Farzan
Nature Reviews Immunology 13 (1), 46-57, 2013
Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry
M Farzan, T Mirzabekov, P Kolchinsky, R Wyatt, M Cayabyab, NP Gerard, ...
Cell 96 (5), 667-676, 1999
Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus
IC Huang, CC Bailey, JL Weyer, SR Radoshitzky, MM Becker, JJ Chiang, ...
PLoS pathogens 7 (1), e1001258, 2011
Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association
J Sui, W Li, A Murakami, A Tamin, LJ Matthews, SK Wong, MJ Moore, ...
Proceedings of the National Academy of Sciences 101 (8), 2536-2541, 2004
The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity
L Zhang, CB Jackson, H Mou, A Ojha, ES Rangarajan, T Izard, M Farzan, ...
BioRxiv, 2020
BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor protein
M Farzan, CE Schnitzler, N Vasilieva, D Leung, H Choe
Proceedings of the national academy of sciences 97 (17), 9712-9717, 2000
IFITM-family proteins: the cell's first line of antiviral defense
CC Bailey, G Zhong, IC Huang, M Farzan
Annual review of virology 1 (1), 261-283, 2014
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