The E3 ubiquitin ligase Ro52 negatively regulates IFN-β production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3 R Higgs, JN Gabhann, NB Larbi, EP Breen, KA Fitzgerald, CA Jefferies The Journal of Immunology 181 (3), 1780-1786, 2008 | 351 | 2008 |
Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23–Th17 pathway A Espinosa, V Dardalhon, S Brauner, A Ambrosi, R Higgs, FJ Quintana, ... Journal of experimental medicine 206 (8), 1661-1671, 2009 | 349 | 2009 |
Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation LA Mielke, SA Jones, M Raverdeau, R Higgs, A Stefanska, JR Groom, ... Journal of Experimental Medicine 210 (6), 1117-1124, 2013 | 337 | 2013 |
Immunity to the respiratory pathogen Bordetella pertussis R Higgs, SC Higgins, PJ Ross, KHG Mills Mucosal immunology 5 (5), 485-500, 2012 | 335 | 2012 |
Bioinformatic discovery and initial characterisation of nine novel antimicrobial peptide genes in the chicken DJ Lynn, R Higgs, S Gaines, J Tierney, T James, AT Lloyd, MA Fares, ... Immunogenetics 56, 170-177, 2004 | 320 | 2004 |
Induction of a Novel Chicken Toll-Like Receptor following Salmonella enterica Serovar Typhimurium Infection R Higgs, P Cormican, S Cahalane, B Allan, AT Lloyd, K Meade, T James, ... Infection and immunity 74 (3), 1692-1698, 2006 | 261 | 2006 |
Avian beta-defensin nomenclature: a community proposed update DJ Lynn, R Higgs, AT Lloyd, C O'Farrelly, V Hervé-Grépinet, Y Nys, ... Immunology letters 110 (1), 86-89, 2007 | 211 | 2007 |
Self protection from anti-viral responses–Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors R Higgs, E Lazzari, C Wynne, J Ní Gabhann, A Espinosa, ... PloS one 5 (7), e11776, 2010 | 168 | 2010 |
The synthetic form of a novel chicken β-defensin identified in silico is predominantly active against intestinal pathogens R Higgs, DJ Lynn, S Gaines, J McMahon, J Tierney, T James, AT Lloyd, ... Immunogenetics 57, 90-98, 2005 | 147 | 2005 |
Antiviral TRIMs: friend or foe in autoimmune and autoinflammatory disease? C Jefferies, C Wynne, R Higgs Nature Reviews Immunology 11 (9), 617-625, 2011 | 115 | 2011 |
Immunotherapy with PI3K Inhibitor and Toll-Like Receptor Agonist Induces IFN-γ+IL-17+ Polyfunctional T Cells That Mediate Rejection of Murine Tumors NA Marshall, KC Galvin, AMB Corcoran, L Boon, R Higgs, KHG Mills Cancer research 72 (3), 581-591, 2012 | 107 | 2012 |
Differential antimicrobial peptide gene expression patterns during early chicken embryological development KG Meade, R Higgs, AT Lloyd, S Giles, C O’Farrelly Developmental & Comparative Immunology 33 (4), 516-524, 2009 | 95 | 2009 |
Absence of SHIP-1 results in constitutive phosphorylation of tank-binding kinase 1 and enhanced TLR3-dependent IFN-β production JN Gabhann, R Higgs, K Brennan, W Thomas, JE Damen, N Ben Larbi, ... The Journal of Immunology 184 (5), 2314-2320, 2010 | 93 | 2010 |
A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine A Dunne, LA Mielke, AC Allen, CE Sutton, R Higgs, CC Cunningham, ... Mucosal immunology 8 (3), 607-617, 2015 | 88 | 2015 |
Modification of chicken avian β-defensin-8 at positively selected amino acid sites enhances specific antimicrobial activity R Higgs, DJ Lynn, S Cahalane, I Alaña, CM Hewage, T James, AT Lloyd, ... Immunogenetics 59, 573-580, 2007 | 48 | 2007 |
Enhanced interferon regulatory factor 3 binding to the interleukin‐23p19 promoter correlates with enhanced interleukin‐23 expression in systemic lupus erythematosus S Smith, JN Gabhann, R Higgs, K Stacey, M Wahren‐Herlenius, ... Arthritis & Rheumatism 64 (5), 1601-1609, 2012 | 39* | 2012 |
Targeting IRFs by ubiquitination: regulating antiviral responses R Higgs, CA Jefferies Biochemical Society Transactions 36 (3), 453-458, 2008 | 38 | 2008 |
TRIM68 negatively regulates IFN-β production by degrading TRK fused gene, a novel driver of IFN-β downstream of anti-viral detection systems C Wynne, E Lazzari, S Smith, EM McCarthy, J Ní Gabhann, LE Kallal, ... PloS one 9 (7), e101503, 2014 | 36 | 2014 |
In silico cloning of new antimicrobial peptides and Toll-like receptor pathway components in the chicken DJ Lynn, R Higgs, S Gaines, T James, AT Lloyd, J Tierney, G Mulcahy, ... Tissue Antigens 64 (4), 333-334, 2004 | 1 | 2004 |
The role of TRIM68 in Toll-like receptor and RIG-I-like receptor induced interferon production (72.5) C Wynne, R Higgs, C Biron, C Jefferies The Journal of Immunology 188 (1_Supplement), 72.5-72.5, 2012 | | 2012 |