| A novel roll-and-slide mechanism of DNA folding in chromatin: implications for nucleosome positioning MY Tolstorukov, AV Colasanti, DM McCandlish, WK Olson, VB Zhurkin Journal of molecular biology 371 (3), 725-738, 2007 | 241 | 2007 |
| Inferring the shape of global epistasis J Otwinowski, DM McCandlish, JB Plotkin Proceedings of the National Academy of Sciences 115 (32), E7550-E7558, 2018 | 181 | 2018 |
| Contingency and entrenchment in protein evolution under purifying selection P Shah, DM McCandlish, JB Plotkin Proceedings of the National Academy of Sciences 112 (25), E3226-E3235, 2015 | 176 | 2015 |
| Modeling evolution using the probability of fixation: history and implications DM McCandlish, A Stoltzfus The Quarterly review of biology 89 (3), 225-252, 2014 | 152 | 2014 |
| Massively parallel assays and quantitative sequence–function relationships JB Kinney, DM McCandlish Annual review of genomics and human genetics 20, 99-127, 2019 | 112 | 2019 |
| Visualizing fitness landscapes DM McCandlish Evolution 65 (6), 1544-1558, 2011 | 107 | 2011 |
| Mutational biases influence parallel adaptation A Stoltzfus, DM McCandlish Molecular biology and evolution 34 (9), 2163-2172, 2017 | 102 | 2017 |
| Epistasis and the dynamics of reversion in molecular evolution DM McCandlish, P Shah, JB Plotkin Genetics 203 (3), 1335-1351, 2016 | 57 | 2016 |
| The role of epistasis in protein evolution DM McCandlish, E Rajon, P Shah, Y Ding, JB Plotkin Nature 497 (7451), E1-E2, 2013 | 57 | 2013 |
| The role of mutation bias in adaptive molecular evolution: insights from convergent changes in protein function JF Storz, C Natarajan, AV Signore, CC Witt, DM McCandlish, A Stoltzfus Philosophical Transactions of the Royal Society B 374 (1777), 20180238, 2019 | 43 | 2019 |
| MAVE-NN: learning genotype-phenotype maps from multiplex assays of variant effect A Tareen, M Kooshkbaghi, A Posfai, WT Ireland, DM McCandlish, ... Genome biology 23 (1), 98, 2022 | 40* | 2022 |
| Mutation bias shapes the spectrum of adaptive substitutions AV Cano, H Rozhoňová, A Stoltzfus, DM McCandlish, JL Payne Proceedings of the National Academy of Sciences 119 (7), e2119720119, 2022 | 34 | 2022 |
| Formal properties of the probability of fixation: identities, inequalities and approximations DM McCandlish, CL Epstein, JB Plotkin Theoretical population biology 99, 98-113, 2015 | 27 | 2015 |
| Cachexia: A systemic consequence of progressive, unresolved disease M Ferrer, TG Anthony, JS Ayres, G Biffi, JC Brown, BJ Caan, ... Cell 186 (9), 1824-1845, 2023 | 25 | 2023 |
| Minimum epistasis interpolation for sequence-function relationships J Zhou, DM McCandlish Nature communications 11 (1), 1782, 2020 | 25 | 2020 |
| Detecting epistasis from an ensemble of adapting populations DM McCandlish, J Otwinowski, JB Plotkin Evolution 69 (9), 2359-2370, 2015 | 22* | 2015 |
| On the findability of genotypes DM McCandlish Evolution 67 (9), 2592-2603, 2013 | 20 | 2013 |
| Higher-order epistasis and phenotypic prediction J Zhou, MS Wong, WC Chen, AR Krainer, JB Kinney, DM McCandlish Proceedings of the National Academy of Sciences 119 (39), e2204233119, 2022 | 15 | 2022 |
| Assortative mating can impede or facilitate fixation of underdominant alleles MG Newberry, DM McCandlish, JB Plotkin Theoretical population biology 112, 14-21, 2016 | 14 | 2016 |
| Designed active-site library reveals thousands of functional GFP variants JY Weinstein, C Martí-Gómez, R Lipsh-Sokolik, SY Hoch, D Liebermann, ... Nature communications 14 (1), 2890, 2023 | 13 | 2023 |
Joshua B. PlotkinAnnenberg Professor of the Natural Sciences, University of PennsylvaniaVerified email at sas.upenn.edu
