| Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex BM Castellano, AM Thelen, O Moldavski, MK Feltes, REN Van Der Welle, ... Science 355 (6331), 1306-1311, 2017 | 475 | 2017 |
| Structural basis of Smoothened regulation by its extracellular domains EFX Byrne, R Sircar, PS Miller, G Hedger, G Luchetti, S Nachtergaele, ... Nature 535 (7613), 517-522, 2016 | 354 | 2016 |
| Mechanism of chemical O-glycosylation: from early studies to recent discoveries LK Mydock, AV Demchenko Organic & biomolecular chemistry 8 (3), 497-510, 2010 | 337 | 2010 |
| Oxysterols are allosteric activators of the oncoprotein Smoothened S Nachtergaele, LK Mydock, K Krishnan, J Rammohan, PH Schlesinger, ... Nature chemical biology 8 (2), 211-220, 2012 | 319 | 2012 |
| Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling S Nachtergaele, DM Whalen, LK Mydock, Z Zhao, T Malinauskas, ... elife 2, e01340, 2013 | 178 | 2013 |
| Development of a bile acid–based newborn screen for Niemann-Pick disease type C X Jiang, R Sidhu, L Mydock-McGrane, FF Hsu, DF Covey, DE Scherrer, ... Science translational medicine 8 (337), 337ra63-337ra63, 2016 | 136 | 2016 |
| Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections L Mydock-McGrane, Z Cusumano, Z Han, J Binkley, M Kostakioti, ... Journal of medicinal chemistry 59 (20), 9390-9408, 2016 | 109 | 2016 |
| Superarming the S-Benzoxazolyl Glycosyl Donors by Simple 2-O-Benzoyl-3,4,6-tri-O-benzyl Protection LK Mydock, AV Demchenko Organic letters 10 (11), 2103-2106, 2008 | 97 | 2008 |
| Rational design strategies for FimH antagonists: new drugs on the horizon for urinary tract infection and Crohn’s disease LK Mydock-McGrane, TJ Hannan, JW Janetka Expert opinion on drug discovery 12 (7), 711-731, 2017 | 96 | 2017 |
| Superarming Common Glycosyl Donors by Simple 2-O-Benzoyl-3,4,6-tri-O-benzyl Protection HD Premathilake, LK Mydock, AV Demchenko The Journal of organic chemistry 75 (4), 1095-1100, 2010 | 90 | 2010 |
| Application of the superarmed glycosyl donor to chemoselective oligosaccharide synthesis LK Mydock, AV Demchenko Organic letters 10 (11), 2107-2110, 2008 | 87 | 2008 |
| Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection V Kalas, ME Hibbing, AR Maddirala, R Chugani, JS Pinkner, ... Proceedings of the National Academy of Sciences 115 (12), E2819-E2828, 2018 | 82 | 2018 |
| Antivirulence isoquinolone mannosides: optimization of the biaryl aglycone for FimH lectin binding affinity and efficacy in the treatment of chronic UTI C Jarvis, Z Han, V Kalas, R Klein, JS Pinkner, B Ford, J Binkley, ... ChemMedChem 11 (4), 367-373, 2016 | 78 | 2016 |
| Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1 MM Budelier, WWL Cheng, L Bergdoll, ZW Chen, JW Janetka, ... Journal of Biological Chemistry 292 (22), 9294-9304, 2017 | 68 | 2017 |
| Mannose-derived FimH antagonists: A promising anti-virulence therapeutic strategy for urinary tract infections and Crohn’s disease LK Mydock-McGrane, ZT Cusumano, JW Janetka Expert opinion on therapeutic patents 26 (2), 175-197, 2016 | 63 | 2016 |
| Direct synthesis of diastereomerically pure glycosyl sulfonium salts LK Mydock, MN Kamat, AV Demchenko Organic letters 13 (11), 2928-2931, 2011 | 49 | 2011 |
| Side-chain oxysterols modulate cholesterol accessibility through membrane remodeling AA Bielska, BN Olsen, SE Gale, L Mydock-McGrane, K Krishnan, ... Biochemistry 53 (18), 3042-3051, 2014 | 38 | 2014 |
| Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel MM Budelier, WWL Cheng, ZW Chen, JR Bracamontes, Y Sugasawa, ... Biochimica Et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2019 | 31 | 2019 |
| Tracking the subcellular fate of 20 (s)-hydroxycholesterol with click chemistry reveals a transport pathway to the Golgi SM Peyrot, S Nachtergaele, G Luchetti, LK Mydock-McGrane, H Fujiwara, ... Journal of Biological Chemistry 289 (16), 11095-11110, 2014 | 26 | 2014 |
| Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain M Kinnebrew, RE Woolley, TB Ansell, EFX Byrne, S Frigui, G Luchetti, ... Science Advances 8 (22), eabm5563, 2022 | 20 | 2022 |
