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Tuo Yang
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Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome
JL Bridgford, SC Xie, SA Cobbold, CFA Pasaje, S Herrmann, T Yang, ...
Nature communications 9 (1), 3801, 2018
2492018
Decreased K13 abundance reduces hemoglobin catabolism and proteotoxic stress, underpinning artemisinin resistance
T Yang, LM Yeoh, MV Tutor, MW Dixon, PJ McMillan, SC Xie, JL Bridgford, ...
Cell reports 29 (9), 2917-2928. e5, 2019
1312019
Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins
SC Xie, C Dogovski, E Hanssen, F Chiu, T Yang, MP Crespo, C Stafford, ...
Journal of Cell Science 129 (2), 406-416, 2016
1282016
Comparison of the exposure time dependence of the activities of synthetic ozonide antimalarials and dihydroartemisinin against K13 wild-type and mutant Plasmodium falciparum …
T Yang, SC Xie, P Cao, C Giannangelo, J McCaw, DJ Creek, ...
Antimicrobial agents and chemotherapy 60 (8), 4501-4510, 2016
602016
MalDA, accelerating malaria drug discovery
T Yang, S Ottilie, ES Istvan, KP Godinez-Macias, AK Lukens, B Baragaña, ...
Trends in parasitology 37 (6), 493-507, 2021
542021
Toxoplasma gondii rhomboid protein 1 (TgROM1) is a potential vaccine candidate against toxoplasmosis
J Li, Q Han, P Gong, T Yang, B Ren, S Li, X Zhang
Veterinary parasitology 184 (2-4), 154-160, 2012
372012
The structure of the PA28–20S proteasome complex from Plasmodium falciparum and implications for proteostasis
SC Xie, RD Metcalfe, E Hanssen, T Yang, DL Gillett, AP Leis, CJ Morton, ...
Nature microbiology 4 (11), 1990-2000, 2019
352019
Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome. Nat Commun 9: 3801
JL Bridgford, SC Xie, SA Cobbold, CFA Pasaje, S Herrmann, T Yang, ...
282018
Parasite-Mediated Degradation of Synthetic Ozonide Antimalarials Impacts In Vitro Antimalarial Activity
C Giannangelo, L Stingelin, T Yang, L Tilley, SA Charman, DJ Creek
Antimicrobial Agents and Chemotherapy 62 (3), 10.1128/aac. 01566-17, 2018
162018
Dimeric artesunate glycerophosphocholine conjugate nano-assemblies as slow-release antimalarials to overcome Kelch 13 mutant artemisinin resistance
Y Du, C Giannangelo, W He, GJ Shami, W Zhou, T Yang, DJ Creek, ...
Antimicrobial Agents and Chemotherapy 66 (5), e02065-21, 2022
112022
Decreased K13 abundance reduces hemoglobin catabolism and proteotoxic stress, underpinning artemisinin resistance. Cell Rep. 2019; 29: 2917–28 e5
T Yang, LM Yeoh, MV Tutor, MW Dixon, PJ McMillan, SC Xie
Curr Opin Microbiol 16, 722-7, 2013
102013
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target
ES Istvan, F Guerra, M Abraham, KS Huang, F Rocamora, H Zhao, L Xu, ...
Science translational medicine 15 (686), eadc9249, 2023
82023
Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome. Nat Commun. 2018; 9: 3801
JL Bridgford, SC Xie, SA Cobbold, CFA Pasaje, S Herrmann, T Yang
5
Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38
JF Armstrong, B Campo, SPH Alexander, LB Arendse, X Cheng, ...
British Journal of Pharmacology 180 (15), 1899-1929, 2023
42023
The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis. Nat Microbiol. 2019; 4: 1990–2000
SC Xie, RD Metcalfe, E Hanssen, T Yang, DL Gillett, AP Leis
2
CRYO-EM OF THE MALARIA PARASITE PA28/20S PROTEASOME COMPLEX REVEALS AN UNUSUAL ACTIVATION MECHANISM WITH IMPLICATIONS FOR ARTEMISININ SENSITIVITY
S Xie, M Griffin, R Metcalfe, E Hanssen, T Yang, D Gilley, A Leis, C Morton, ...
PROTEIN SCIENCE 28, 55-56, 2019
2019
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