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Stanley C Xie
Stanley C Xie
Verified email at unimelb.edu.au
Title
Cited by
Cited by
Year
Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance
C Dogovski, SC Xie, G Burgio, J Bridgford, S Mok, JM McCaw, ...
PLoS biology 13 (4), e1002132, 2015
3382015
Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome
JL Bridgford, SC Xie, SA Cobbold, CFA Pasaje, S Herrmann, T Yang, ...
Nature communications 9 (1), 3801, 2018
2442018
Structure- and function-based design of Plasmodium-selective proteasome inhibitors
H Li, AJ O’Donoghue, WA van der Linden, SC Xie, E Yoo, IT Foe, L Tilley, ...
Nature 530 (7589), 233-236, 2016
2412016
Altered temporal response of malaria parasites determines differential sensitivity to artemisinin
N Klonis, SC Xie, JM McCaw, MP Crespo-Ortiz, SG Zaloumis, JA Simpson, ...
Proceedings of the National Academy of Sciences 110 (13), 5157-5162, 2013
2222013
Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance
T Yang, LM Yeoh, MV Tutor, MW Dixon, PJ McMillan, SC Xie, JL Bridgford, ...
Cell reports 29 (9), 2917-2928. e5, 2019
1292019
Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins
SC Xie, C Dogovski, E Hanssen, F Chiu, T Yang, MP Crespo, C Stafford, ...
Journal of cell science 129 (2), 406-416, 2016
1282016
K13, the cytostome, and artemisinin resistance
SC Xie, SA Ralph, L Tilley
Trends in parasitology 36 (6), 533-544, 2020
722020
Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome
SC Xie, DL Gillett, NJ Spillman, C Tsu, MR Luth, S Ottilie, S Duffy, ...
Journal of medicinal chemistry 61 (22), 10053-10066, 2018
612018
Comparison of the exposure time dependence of the activities of synthetic ozonide antimalarials and dihydroartemisinin against K13 wild-type and mutant Plasmodium falciparum …
T Yang, SC Xie, P Cao, C Giannangelo, J McCaw, DJ Creek, ...
Antimicrobial agents and chemotherapy 60 (8), 4501-4510, 2016
602016
The proteasome as a target for protozoan parasites
SC Xie, LR Dick, A Gould, S Brand, L Tilley
Expert opinion on therapeutic targets 23 (11), 903-914, 2019
362019
The structure of the PA28–20S proteasome complex from Plasmodium falciparum and implications for proteostasis
SC Xie, RD Metcalfe, E Hanssen, T Yang, DL Gillett, AP Leis, CJ Morton, ...
Nature microbiology 4 (11), 1990-2000, 2019
352019
Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy
SC Xie, RD Metcalfe, E Dunn, CJ Morton, SC Huang, T Puhalovich, Y Du, ...
Science 376 (6597), 1074-1079, 2022
262022
Optimal assay design for determining the in vitro sensitivity of ring stage Plasmodium falciparum to artemisinins
SC Xie, C Dogovski, S Kenny, L Tilley, N Klonis
International journal for parasitology 44 (12), 893-899, 2014
242014
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome
SC Xie, RD Metcalfe, H Mizutani, T Puhalovich, E Hanssen, CJ Morton, ...
Proceedings of the National Academy of Sciences 118 (39), e2107213118, 2021
192021
A dynamic stress model explains the delayed drug effect in artemisinin treatment of Plasmodium falciparum
P Cao, N Klonis, S Zaloumis, C Dogovski, SC Xie, S Saralamba, LJ White, ...
Antimicrobial agents and chemotherapy 61 (12), 10.1128/aac. 00618-17, 2017
132017
Targeting Aminoacyl tRNA Synthetases for Antimalarial Drug Development
SC Xie, MDW Griffin, EA Winzeler, L Ribas de Pouplana, L Tilley
Annual Review of Microbiology 77, 111-129, 2023
52023
High Throughput Screening to Identify Selective and Nonpeptidomimetic Proteasome Inhibitors As Antimalarials
L Mata-Cantero, SC Xie, M García, J Coyle, R Fernandez, AC Cabrera, ...
ACS Infectious Diseases 7 (6), 1818-1832, 2021
32021
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase
SC Xie, Y Wang, CJ Morton, RD Metcalfe, C Dogovski, CFA Pasaje, ...
Nature Communications 15 (1), 937, 2024
2024
Reaction hijacking ATP-activated enzymes as a strategy to develop new anti-infectives
S Xie, R Metcalfe, E Dunn, C Morton, S Huang, S Wittlin, E Winzeler, ...
FEBS OPEN BIO 12, 23-23, 2022
2022
CRYO-EM OF THE MALARIA PARASITE PA28/20S PROTEASOME COMPLEX REVEALS AN UNUSUAL ACTIVATION MECHANISM WITH IMPLICATIONS FOR ARTEMISININ SENSITIVITY
S Xie, M Griffin, R Metcalfe, E Hanssen, T Yang, D Gilley, A Leis, C Morton, ...
PROTEIN SCIENCE 28, 55-56, 2019
2019
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