| Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate SF Sleiman, J Henry, R Al-Haddad, L El Hayek, E Abou Haidar, T Stringer, ... elife 5, e15092, 2016 | 720 | 2016 |
| Selenium drives a transcriptional adaptive program to block ferroptosis and treat stroke I Alim, JT Caulfield, Y Chen, V Swarup, DH Geschwind, E Ivanova, ... Cell 177 (5), 1262-1279. e25, 2019 | 654 | 2019 |
| Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease SS Karuppagounder, JT Pinto, H Xu, HL Chen, MF Beal, GE Gibson Neurochemistry international 54 (2), 111-118, 2009 | 578 | 2009 |
| Neuronal death after hemorrhagic stroke in vitro and in vivo shares features of ferroptosis and necroptosis M Zille, SS Karuppagounder, Y Chen, PJ Gough, J Bertin, J Finger, ... Stroke 48 (4), 1033-1043, 2017 | 427 | 2017 |
| N‐acetylcysteine targets 5 lipoxygenase‐derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following … SS Karuppagounder, L Alin, Y Chen, D Brand, MW Bourassa, K Dietrich, ... Annals of neurology 84 (6), 854-872, 2018 | 227 | 2018 |
| Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson’s disease in rats SS Karuppagounder, SK Madathil, M Pandey, R Haobam, U Rajamma, ... Neuroscience 236, 136-148, 2013 | 213 | 2013 |
| Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model SS Karuppagounder, H Xu, Q Shi, LH Chen, S Pedrini, D Pechman, ... Neurobiology of aging 30 (10), 1587-1600, 2009 | 158 | 2009 |
| Acute intranigral infusion of rotenone in rats causes progressive biochemical lesions in the striatum similar to Parkinson's disease KS Saravanan, KM Sindhu, KP Mohanakumar Brain research 1049 (2), 147-155, 2005 | 156 | 2005 |
| Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by “antioxidant” metal chelators: From ferroptosis to stroke RE Speer, SS Karuppagounder, M Basso, SF Sleiman, A Kumar, D Brand, ... Free Radical Biology and Medicine 62, 26-36, 2013 | 145 | 2013 |
| Melatonin protects against rotenone‐induced oxidative stress in a hemiparkinsonian rat model KS Saravanan, KM Sindhu, KP Mohanakumar Journal of pineal research 42 (3), 247-253, 2007 | 143 | 2007 |
| Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models SS Karuppagounder, I Alim, SJ Khim, MW Bourassa, SF Sleiman, R John, ... Science translational medicine 8 (328), 328ra29-328ra29, 2016 | 126 | 2016 |
| Hypoxia-inducible factor prolyl hydroxylase inhibition: robust new target or another big bust for stroke therapeutics? SS Karuppagounder, RR Ratan Journal of Cerebral Blood Flow & Metabolism 32 (7), 1347-1361, 2012 | 125 | 2012 |
| Non-steroidal anti-inflammatory drug sodium salicylate, but not diclofenac or celecoxib, protects against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats K Sairam, KS Saravanan, R Banerjee, KP Mohanakumar Brain Research 966 (2), 245-252, 2003 | 121 | 2003 |
| Acetaminophen and aspirin inhibit superoxide anion generation and lipid peroxidation, and protect against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats DS Maharaj, KS Saravanan, H Maharaj, KP Mohanakumar, S Daya Neurochemistry international 44 (5), 355-360, 2004 | 103 | 2004 |
| Behavioral differences in a rotenone-induced hemiparkinsonian rat model developed following intranigral or median forebrain bundle infusion KM Sindhu, KS Saravanan, KP Mohanakumar Brain research 1051 (1-2), 25-34, 2005 | 98 | 2005 |
| L-deprenyl protects against rotenone-induced, oxidative stress-mediated dopaminergic neurodegeneration in rats KS Saravanan, KM Sindhu, KS Senthilkumar, KP Mohanakumar Neurochemistry international 49 (1), 28-40, 2006 | 92 | 2006 |
| Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism SS Karuppagounder, Q Shi, H Xu, GE Gibson Neurobiology of disease 26 (2), 353-362, 2007 | 69 | 2007 |
| Rats with unilateral median forebrain bundle, but not striatal or nigral, lesions by the neurotoxins MPP+ or rotenone display differential sensitivity to amphetamine and … KM Sindhu, R Banerjee, KS Senthilkumar, KS Saravanan, BC Raju, ... Pharmacology Biochemistry and Behavior 84 (2), 321-329, 2006 | 68 | 2006 |
| Ferroptosis in neurons and cancer cells is similar but differentially regulated by histone deacetylase inhibitors M Zille, A Kumar, N Kundu, MW Bourassa, VSC Wong, D Willis, ... eneuro 6 (1), 2019 | 62 | 2019 |
| Oxidant‐induced changes in mitochondria and calcium dynamics in the pathophysiology of Alzheimer's disease GE Gibson, SS Karuppagounder, Q Shi Annals of the New York Academy of Sciences 1147 (1), 221-232, 2008 | 61 | 2008 |
Rajiv R. RatanExecutive Director, Burke Medical Research Institute, Burke Professor of Neurology and NeuroscienceVerified email at med.cornell.edu
