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Gareth Prosser
Gareth Prosser
Senior Biologist, University of Dundee
Verified email at dundee.ac.uk
Title
Cited by
Cited by
Year
Metabolomic strategies for the identification of new enzyme functions and metabolic pathways
GA Prosser, G Larrouy‐Maumus, LPS de Carvalho
EMBO reports 15 (6), 657-669, 2014
1292014
Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954
GA Prosser, JN Copp, SP Syddall, EM Williams, JB Smaill, WR Wilson, ...
Biochemical pharmacology 79 (5), 678-687, 2010
1282010
Kinetic mechanism and inhibition of Mycobacterium tuberculosis d‐alanine:d‐alanine ligase by the antibiotic d‐cycloserine
GA Prosser, LPS de Carvalho
The FEBS journal 280 (4), 1150-1166, 2013
1262013
Metabolomics Reveal d-Alanine:d-Alanine Ligase As the Target of d-Cycloserine in Mycobacterium tuberculosis
GA Prosser, LPS de Carvalho
ACS medicinal chemistry letters 4 (12), 1233-1237, 2013
1112013
The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition
G Prosser, J Brandenburg, N Reiling, CE Barry III, RJ Wilkinson, ...
Microbes and infection 19 (3), 177-192, 2017
762017
Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A
GA Prosser, JN Copp, AM Mowday, CP Guise, SP Syddall, EM Williams, ...
Biochemical pharmacology 85 (8), 1091-1103, 2013
592013
2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure–Activity Relationships, Mechanism of Action …
D Murugesan, PC Ray, T Bayliss, GA Prosser, JR Harrison, K Green, ...
ACS infectious diseases 4 (6), 954-969, 2018
562018
Reinterpreting the Mechanism of Inhibition of Mycobacterium tuberculosis d-Alanine:d-Alanine Ligase by d-Cycloserine
GA Prosser, LPS de Carvalho
Biochemistry 52 (40), 7145-7149, 2013
522013
Metabolomics of Mycobacterium tuberculosis
M Nandakumar, GA Prosser, LPS de Carvalho, K Rhee
Mycobacteria Protocols, 105-115, 2015
462015
Glutamate Racemase Is the Primary Target of β-Chloro-d-Alanine in Mycobacterium tuberculosis
GA Prosser, A Rodenburg, H Khoury, C de Chiara, S Howell, AP Snijders, ...
Antimicrobial agents and chemotherapy 60 (10), 6091-6099, 2016
432016
Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes
D Evangelopoulos, GA Prosser, A Rodgers, BM Dagg, B Khatri, MM Ho, ...
Nature communications 10 (1), 4177, 2019
362019
Role of post‐translational modifications in the acquisition of drug resistance in Mycobacterium tuberculosis
G Arora, A Bothra, G Prosser, K Arora, A Sajid
The FEBS Journal 288 (11), 3375-3393, 2021
342021
d-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition
C de Chiara, M Homšak, GA Prosser, HL Douglas, A Garza-Garcia, ...
Nature chemical biology 16 (6), 686-694, 2020
332020
uvrB gene deletion enhances SOS chromotest sensitivity for nitroreductases that preferentially generate the 4-hydroxylamine metabolite of the anti-cancer prodrug CB1954
GA Prosser, AV Patterson, DF Ackerley
Journal of biotechnology 150 (1), 190-194, 2010
242010
Development and optimization of chromosomally-integrated fluorescent Mycobacterium tuberculosis reporter constructs
K Kolbe, AC Bell, GA Prosser, M Assmann, HE Forbes, KD Mayer-Barber, ...
Frontiers in microbiology 11, 591866, 2020
102020
A gain-of-function positive-selection expression plasmid that enables high-efficiency cloning
GA Prosser, EM Williams, JA Sissons, KE Walmsley, MR Parker, ...
Biotechnology letters 37, 383-389, 2015
72015
Bacterial nitroreductase enzymes and methods relating thereto
CP Guise, DF Ackerley, A Ashoorzadeh, JN Copp, JU Flanagan, ...
US Patent 10,357,577, 2019
62019
Restoring tumour selectivity of the bioreductive prodrug PR-104 by developing an analogue resistant to aerobic metabolism by human aldo-keto reductase 1C3
MR Abbattista, A Ashoorzadeh, CP Guise, AM Mowday, R Mittra, S Silva, ...
Pharmaceuticals 14 (12), 1231, 2021
52021
Antibiotic resistance evasion is explained by rare mutation frequency and not by lack of compensatory mechanisms
D Evangelopoulos, GA Prosser, A Rodgers, BM Dagg, B Khatri, MM Ho, ...
BioRxiv, 374215, 2018
22018
Structure of the d-Cycloserine-Resistant Variant D322N of Alanine Racemase from Mycobacterium tuberculosis
C de Chiara, GA Prosser, R Ogrodowicz, LPS de Carvalho
ACS bio & med Chem Au 3 (3), 233-239, 2023
12023
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