Carlos J. Orihuela
Carlos J. Orihuela
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Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice
RA Miller, DE Harrison, CM Astle, JA Baur, AR Boyd, R De Cabo, ...
The Journals of Gerontology: Series A 66 (2), 191-201, 2011
Tissue-specific contributions of pneumococcal virulence factors to pathogenesis
CJ Orihuela, G Gao, KP Francis, J Yu, EI Tuomanen
Journal of Infectious Diseases 190 (9), 1661-1669, 2004
Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models
CJ Orihuela, J Mahdavi, J Thornton, B Mann, KG Wooldridge, ...
The Journal of clinical investigation 119 (6), 1638-1646, 2009
Microarray analysis of pneumococcal gene expression during invasive disease
CJ Orihuela, JN Radin, JE Sublett, G Gao, D Kaushal, EI Tuomanen
Infection and immunity 72 (10), 5582-5596, 2004
Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells
L Xue, SW Morris, C Orihuela, E Tuomanen, X Cui, R Wen, D Wang
Nature immunology 4 (9), 857-865, 2003
The Pneumococcal Serine-Rich Repeat Protein Is an Intra-Species Bacterial Adhesin That Promotes Bacterial Aggregation In Vivo and in Biofilms
CJ Sanchez, P Shivshankar, K Stol, S Trakhtenbroit, PM Sullam, K Sauer, ...
PLoS pathogens 6 (8), e1001044, 2010
Identification of a Candidate Streptococcus pneumoniae Core Genome and Regions of Diversity Correlated with Invasive Pneumococcal Disease
C Obert, J Sublett, D Kaushal, E Hinojosa, T Barton, EI Tuomanen, ...
Infection and immunity 74 (8), 4766-4777, 2006
Pore-forming toxins induce macrophage necroptosis during acute bacterial pneumonia
N González-Juarbe, RP Gilley, CA Hinojosa, KM Bradley, A Kamei, G Gao, ...
PLoS pathogens 11 (12), e1005337, 2015
Streptococcus pneumoniae Translocates into the Myocardium and Forms Unique Microlesions That Disrupt Cardiac Function
AO Brown, B Mann, G Gao, JS Hankins, J Humann, J Giardina, P Faverio, ...
PLoS pathogens 10 (9), e1004383, 2014
β-Arrestin 1 Participates in Platelet-Activating Factor Receptor-Mediated Endocytosis of Streptococcus pneumoniae
JN Radin, CJ Orihuela, G Murti, C Guglielmo, PJ Murray, EI Tuomanen
Infection and immunity 73 (12), 7827-7835, 2005
Induction of pro-and anti-inflammatory molecules in a mouse model of pneumococcal pneumonia after influenza
MW Smith, JE Schmidt, JE Rehg, CJ Orihuela, JA McCullers
Comparative medicine 57 (1), 82-89, 2007
The Streptococcus pneumoniae adhesin PsrP binds to Keratin 10 on lung cells
P Shivshankar, C Sanchez, LF Rose, CJ Orihuela
Molecular microbiology 73 (4), 663-679, 2009
Age-associated inflammation and toll-like receptor dysfunction prime the lungs for pneumococcal pneumonia
E Hinojosa, AR Boyd, CJ Orihuela
The Journal of infectious diseases 200 (4), 546-554, 2009
Streptococcus pneumoniae in Biofilms Are Unable to Cause Invasive Disease Due to Altered Virulence Determinant Production
CJ Sanchez, N Kumar, A Lizcano, P Shivshankar, JC Dunning Hotopp, ...
PloS one 6 (12), e28738, 2011
Incidence of cardiovascular events after hospital admission for pneumonia
TW Perry, MJV Pugh, GW Waterer, B Nakashima, CJ Orihuela, ...
The American journal of medicine 124 (3), 244-251, 2011
Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease
JW Rosch, AR Boyd, E Hinojosa, T Pestina, Y Hu, DA Persons, ...
The Journal of clinical investigation 120 (2), 627-635, 2010
Virulence in mice of pneumococcal clonal types with known invasive disease potential in humans
A Sandgren, B Albiger, CJ Orihuela, E Tuomanen, S Normark, ...
The Journal of infectious diseases 192 (5), 791-800, 2005
Age-related defects in TLR2 signaling diminish the cytokine response by alveolar macrophages during murine pneumococcal pneumonia
AR Boyd, P Shivshankar, S Jiang, MT Berton, CJ Orihuela
Experimental gerontology 47 (7), 507-518, 2012
Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia
P Shivshankar, AR Boyd, CJ Le Saux, IT Yeh, CJ Orihuela
Aging cell 10 (5), 798-806, 2011
A role for glycosylated serine‐rich repeat proteins in gram‐positive bacterial pathogenesis
A Lizcano, CJ Sanchez, CJ Orihuela
Molecular oral microbiology 27 (4), 257-269, 2012
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