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Natasha Grimsey
Natasha Grimsey
Senior Research Fellow, University of Auckland, New Zealand
Verified email at auckland.ac.nz - Homepage
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Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists
A Gillis, AB Gondin, A Kliewer, J Sanchez, HD Lim, C Alamein, ...
Science Signaling 13 (625), eaaz3140, 2020
1372020
Specific detection of CB1 receptors; cannabinoid CB1 receptor antibodies are not all created equal!
NL Grimsey, CE Goodfellow, EL Scotter, MJ Dowie, M Glass, ES Graham
Journal of neuroscience methods 171 (1), 78-86, 2008
1362008
Real‐time characterization of cannabinoid receptor 1 (CB1) allosteric modulators reveals novel mechanism of action
EE Cawston, WJ Redmond, CM Breen, NL Grimsey, M Connor, M Glass
British Journal of Pharmacology 170 (4), 893-907, 2013
932013
Cannabinoid receptor 2 undergoes Rab5-mediated internalization and recycles via a Rab11-dependent pathway
NL Grimsey, CE Goodfellow, M Dragunow, M Glass
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1813 (8), 1554-1560, 2011
742011
GPR18 undergoes a high degree of constitutive trafficking but is unresponsive to N-Arachidonoyl Glycine
DB Finlay, WR Joseph, NL Grimsey*, M Glass*
PeerJ 4, e1835, 2016
582016
Cannabinoid receptor 1 trafficking and the role of the intracellular pool: implications for therapeutics
NL Grimsey, ES Graham, M Dragunow, M Glass
Biochemical pharmacology 80 (7), 1050-1062, 2010
582010
s signalling of the CB1 receptor and the influence of receptor number
DB Finlay, EE Cawston, NL Grimsey, MR Hunter, A Korde, VK Vemuri, ...
British journal of pharmacology 174 (15), 2545-2562, 2017
512017
Cannabinoid CB1 and CB2 receptor-mediated arrestin translocation: species, subtype, and agonist-dependence
MS Ibsen, DB Finlay, M Patel, JA Javitch, M Glass, NL Grimsey
Frontiers in pharmacology 10, 350, 2019
332019
Cannabinoid receptor CB2 is expressed on vascular cells, but not astroglial cells in the post-mortem human Huntington's disease brain
MJ Dowie, NL Grimsey, T Hoffman, RLM Faull, M Glass
Journal of Chemical Neuroanatomy, 2014
322014
Cannabinoid Receptor 2 (CB2) Signals via G-alpha-s and Induces IL-6 and IL-10 Cytokine Secretion in Human Primary Leukocytes
Y Saroz, DT Kho, M Glass, ES Graham, NL Grimsey
ACS Pharmacology and Translational Science, https://doi.org/10.1021/acsptsci …, 2019
292019
A novel high‐throughput assay for the quantitative assessment of receptor trafficking
NL Grimsey, PJ Narayan, M Dragunow, M Glass
Clinical and Experimental Pharmacology and Physiology 35 (11), 1377-1382, 2008
262008
Identification of N‐arachidonoyl dopamine as a highly biased ligand at cannabinoid CB1 receptors
WJ Redmond, EE Cawston, NL Grimsey, J Stuart, AR Edington, M Glass, ...
British Journal of Pharmacology 173 (1), 115-127, 2016
252016
Signalling profiles of a structurally diverse panel of synthetic cannabinoid receptor agonists
M Patel, JJ Manning, DB Finlay, JA Javitch, SD Banister, NL Grimsey, ...
Biochemical Pharmacology 175, 113871, 2020
192020
Chromenopyrazole-based high affinity, selective fluorescent ligands for cannabinoid type 2 receptor
S Singh, CRM Oyagawa, C Macdonald, NL Grimsey, M Glass, AJ Vernall
ACS medicinal chemistry letters 10 (2), 209-214, 2019
142019
Cannabinoid Receptor 2 Signalling Bias Elicited by 2,4,6-Trisubstituted 1,3,5-Triazines
CRM Oyagawa, SM de la Harpe, Y Saroz, M Glass, AJ Vernall, ...
Frontiers in Pharmacology 9, 1202, 2018
122018
Sensitive and accurate quantification of human leukocyte migration using high-content Discovery-1 imaging system and ATPlite assay
NL Grimsey, KS Moodley, M Glass, ES Graham
Journal of biomolecular screening 17 (3), 386-393, 2012
112012
Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells
R Sarott, M Westphal, P Pfaff, C Korn, D Sykes, G Thais, B Brennecke, ...
Journal of the American Chemical Society 142, 16953-64, 2020
102020
Real-time measurement of cannabinoid receptor-mediated cAMP signaling
MR Hunter, DB Finlay, CE Macdonald, EE Cawston, NL Grimsey, M Glass
Methods in Enzymology 593, 43-59, 2017
102017
Sulfation of the FLAG epitope is affected by co-expression of G protein-coupled receptors in a mammalian cell model
MR Hunter, NL Grimsey, M Glass
Scientific reports 6 (1), 1-10, 2016
102016
Regulating membrane lipid levels at the synapse by small-molecule inhibitors of monoacylglycerol lipase: new developments in therapeutic and PET imaging applications
NL Grimsey, JR Savinainen, B Attili, M Ahamed
Drug Discovery Today, 2019
92019
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