Drug resistance and treatment failure in leishmaniasis: A 21st century challenge A Ponte-Sucre, F Gamarro, JC Dujardin, MP Barrett, R López-Vélez, ... PLoS neglected tropical diseases 11 (12), e0006052, 2017 | 844 | 2017 |
Leishmaniasis: drugs in the clinic, resistance and new developments M Ouellette, J Drummelsmith, B Papadopoulou Drug Resistance Updates 7 (4-5), 257-266, 2004 | 558 | 2004 |
Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages C Dumas, M Ouellette, J Tovar, ML Cunningham, AH Fairlamb, S Tamar, ... The EMBO journal, 1997 | 398 | 1997 |
The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase D Légaré, D Richard, R Mukhopadhyay, YD Stierhof, BP Rosen, ... Journal of Biological Chemistry 276 (28), 26301-26307, 2001 | 292 | 2001 |
Developmental regulation of gene expression in trypanosomatid parasitic protozoa S Haile, B Papadopoulou Current opinion in microbiology 10 (6), 569-577, 2007 | 285 | 2007 |
A novel antifolate resistance gene on the amplified H circle of Leishmania. B Papadopoulou, G Roy, M Ouellette The EMBO journal 11 (10), 3601-3608, 1992 | 235 | 1992 |
Rab5 regulates the kiss and run fusion between phagosomes and endosomes and the acquisition of phagosome leishmanicidal properties in RAW 264.7 macrophages S Duclos, R Diez, J Garin, B Papadopoulou, A Descoteaux, H Stenmark, ... Journal of cell science 113 (19), 3531-3541, 2000 | 232 | 2000 |
A combined proteomic and transcriptomic approach to the study of stage differentiation in Leishmania infantum F McNicoll, J Drummelsmith, M Müller, É Madore, N Boilard, M Ouellette, ... Proteomics 6 (12), 3567-3581, 2006 | 216 | 2006 |
A common mechanism of stage-regulated gene expression in Leishmania mediated by a conserved 3′-untranslated region element N Boucher, Y Wu, C Dumas, M Dubé, D Sereno, M Breton, ... Journal of Biological Chemistry 277 (22), 19511-19520, 2002 | 215 | 2002 |
Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy JM Ubeda, D Légaré, F Raymond, AA Ouameur, S Boisvert, P Rigault, ... Genome biology 9, 1-16, 2008 | 210 | 2008 |
Episomal and stable expression of the luciferase reporter gene for quantifying Leishmania spp. infections in macrophages and in animal models G Roy, C Dumas, D Sereno, Y Wu, AK Singh, MJ Tremblay, M Ouellette, ... Molecular and biochemical parasitology 110 (2), 195-206, 2000 | 207 | 2000 |
Genome sequencing of the lizard parasite Leishmania tarentolae reveals loss of genes associated to the intracellular stage of human pathogenic species F Raymond, S Boisvert, G Roy, JF Ritt, D Legare, A Isnard, M Stanke, ... Nucleic acids research 40 (3), 1131-1147, 2012 | 203 | 2012 |
Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between … A Rochette, F Raymond, JM Ubeda, M Smith, N Messier, S Boisvert, ... BMC genomics 9, 1-26, 2008 | 181 | 2008 |
Live nonpathogenic parasitic vector as a candidate vaccine against visceral leishmaniasis M Breton, MJ Tremblay, M Ouellette, B Papadopoulou Infection and immunity 73 (10), 6372-6382, 2005 | 181 | 2005 |
An ATP-dependent As (III)-glutathione transport system in membrane vesicles of Leishmania tarentolae. S Dey, M Ouellette, J Lightbody, B Papadopoulou, BP Rosen Proceedings of the National Academy of Sciences 93 (5), 2192-2197, 1996 | 181 | 1996 |
Role of the ABC Transporter MRPA (PGPA) in Antimony Resistance in Leishmania infantum Axenic and Intracellular Amastigotes K El Fadili, N Messier, P Leprohon, G Roy, C Guimond, N Trudel, ... Antimicrobial agents and chemotherapy 49 (5), 1988-1993, 2005 | 176 | 2005 |
Amplification of the ABC transporter gene PGPA and increased trypanothione levels in potassium antimonyl tartrate (SbIII) resistant Leishmania tarentolae. A Haimeur, C Brochu, PA Genest, B Papadopoulou, M Ouellette | 170 | 2000 |
Mechanisms of drug resistance in Leishmania M Ouellette, B Papadopoulou Parasitology Today 9 (5), 150-153, 1993 | 168 | 1993 |
Contribution of the Leishmania P-glycoprotein-related gene ltpgpA to oxyanion resistance. B Papadopoulou, G Roy, S Dey, BP Rosen, M Ouellette Journal of Biological Chemistry 269 (16), 11980-11986, 1994 | 158 | 1994 |
A new developmentally regulated gene family in Leishmania amastigotes encoding a homolog of amastin surface proteins Y Wu, Y El Fakhry, D Sereno, S Tamar, B Papadopoulou Molecular and biochemical parasitology 110 (2), 345-357, 2000 | 156 | 2000 |