| The inhibitors of apoptosis (IAPs) and their emerging role in cancer EC LaCasse, S Baird, RG Korneluk, AE MacKenzie Oncogene 17 (25), 3247-3259, 1998 | 1518 | 1998 |
| The inhibitors of apoptosis (IAPs) as cancer targets AM Hunter, EC LaCasse, RG Korneluk Apoptosis 12 (9), 1543-1568, 2007 | 776 | 2007 |
| IAP-targeted therapies for cancer EC LaCasse, DJ Mahoney, HH Cheung, S Plenchette, S Baird, ... Oncogene 27 (48), 6252-6275, 2008 | 718 | 2008 |
| Both cIAP1 and cIAP2 regulate TNFα-mediated NF-κB activation DJ Mahoney, HH Cheung, RL Mrad, S Plenchette, C Simard, E Enwere, ... Proceedings of the National Academy of Sciences 105 (33), 11778-11783, 2008 | 643 | 2008 |
| Marked induction of the IAP family antiapoptotic proteins survivin and XIAP by VEGF in vascular endothelial cells J Tran, J Rak, C Sheehan, SD Saibil, E LaCasse, RG Korneluk, RS Kerbel Biochemical and biophysical research communications 264 (3), 781-788, 1999 | 539 | 1999 |
| Antisense Oligonucleotides Targeting XIAP Induce Apoptosis and Enhance Chemotherapeutic Activity against Human Lung Cancer Cells in Vitro and in Vivo YP Hu, G Cherton-Horvat, V Dragowska, S Baird, RG Korneluk, JP Durkin, ... Clinical cancer research 9 (7), 2826-2836, 2003 | 324 | 2003 |
| Nuclear localization signals overlap DNA-or RNA-binding domains in nucleic acid-binding proteins. EC LaCasse, YA Lefebvre Nucleic acids research 23 (10), 1647, 1995 | 317 | 1995 |
| Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival D Conte, M Holcik, CA Lefebvre, E LaCasse, DJ Picketts, KE Wright, ... Molecular and cellular biology 26 (2), 699-708, 2006 | 242 | 2006 |
| Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics DC McManus, CA Lefebvre, G Cherton-Horvat, M St-Jean, ER Kandimalla, ... Oncogene 23 (49), 8105-8117, 2004 | 224 | 2004 |
| Baculoviral IAP repeat-containing-4 protects optic nerve axons in a rat glaucoma model SJ McKinnon, DM Lehman, NG Tahzib, NL Ransom, HA Reitsamer, ... Molecular Therapy 5 (6), 780-787, 2002 | 190 | 2002 |
| Preclinical characterization of AEG35156/GEM 640, a second-generation antisense oligonucleotide targeting X-linked inhibitor of apoptosis EC LaCasse, GG Cherton-Horvat, KE Hewitt, LJ Jerome, SJ Morris, ... Clinical cancer research 12 (17), 5231-5241, 2006 | 180 | 2006 |
| Modulation of immune signalling by inhibitors of apoptosis ST Beug, HH Cheung, EC LaCasse, RG Korneluk Trends in immunology 33 (11), 535-545, 2012 | 170 | 2012 |
| Smac mimetics and innate immune stimuli synergize to promote tumor death ST Beug, VA Tang, EC LaCasse, HH Cheung, CE Beauregard, J Brun, ... Nature biotechnology 32 (2), 182-190, 2014 | 144 | 2014 |
| Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary … AD Schimmer, EH Estey, G Borthakur, BZ Carter, GJ Schiller, MS Tallman, ... Journal of Clinical Oncology 27 (28), 4741, 2009 | 137 | 2009 |
| Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma ST Beug, CE Beauregard, C Healy, T Sanda, M St-Jean, J Chabot, ... Nature Communications 8 (1), 14278, 2017 | 129 | 2017 |
| Shiga-Like Toxin-1 Receptor on Human Breast Cancer, Lymphoma, and Myeloma and Absence From CD34+ Hematopoietic Stem Cells: Implications for Ex Vivo … EC LaCasse, MR Bray, B Patterson, WM Lim, S Perampalam, ... Blood, The Journal of the American Society of Hematology 94 (8), 2901-2910, 1999 | 127 | 1999 |
| Recruitment of octamer transcription factors to DNA by glucocorticoid receptor GG Préfontaine, ME Lemieux, W Giffin, C Schild-Poulter, L Pope, ... Molecular and cellular biology 18 (6), 3416-3430, 1998 | 123 | 1998 |
| Inhibitors of apoptosis (IAPs) regulate intestinal immunity and inflammatory bowel disease (IBD) inflammation J Pedersen, EC LaCasse, JB Seidelin, M Coskun, OH Nielsen Trends in Molecular Medicine 20 (11), 652-665, 2014 | 114 | 2014 |
| Phase I trial of AEG35156 administered as a 7-day and 3-day continuous intravenous infusion in patients with advanced refractory cancer E Dean, D Jodrell, K Connolly, S Danson, J Jolivet, J Durkin, S Morris, ... Journal of clinical oncology 27 (10), 1660-1666, 2009 | 113 | 2009 |
| XIAP protection of photoreceptors in animal models of retinitis pigmentosa KC Leonard, D Petrin, SG Coupland, AN Baker, BC Leonard, ... PloS one 2 (3), e314, 2007 | 112 | 2007 |
