Isabelle Lucet
Isabelle Lucet
Associate Professor
Verified email at wehi.edu.au
Title
Cited by
Cited by
Year
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism
JM Murphy, PE Czabotar, JM Hildebrand, IS Lucet, JG Zhang, ...
Immunity 39 (3), 443-453, 2013
8162013
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
JM Hildebrand, MC Tanzer, IS Lucet, SN Young, SK Spall, P Sharma, ...
Proceedings of the National Academy of Sciences 111 (42), 15072-15077, 2014
3762014
The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor
IS Lucet, E Fantino, M Styles, R Bamert, O Patel, SE Broughton, M Walter, ...
Blood 107 (1), 176-183, 2006
2892006
Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity
JJ Babon, NJ Kershaw, JM Murphy, LN Varghese, A Laktyushin, ...
Immunity 36 (2), 239-250, 2012
2512012
Differential recognition of CD1d-α-galactosyl ceramide by the Vβ8. 2 and Vβ7 semi-invariant NKT T cell receptors
DG Pellicci, O Patel, L Kjer-Nielsen, SS Pang, LC Sullivan, ...
Immunity 31 (1), 47-59, 2009
2382009
The molecular regulation of Janus kinase (JAK) activation
JJ Babon, IS Lucet, JM Murphy, NA Nicola, LN Varghese
Biochemical Journal 462 (1), 1-13, 2014
2322014
SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition
NJ Kershaw, JM Murphy, NPD Liau, LN Varghese, A Laktyushin, ...
Nature structural & molecular biology 20 (4), 469-476, 2013
2242013
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties
JM Murphy, Q Zhang, SN Young, ML Reese, FP Bailey, PA Eyers, ...
Biochemical Journal 457 (2), 323-334, 2014
2112014
Open source drug discovery with the malaria box compound collection for neglected diseases and beyond
WC Van Voorhis, JH Adams, R Adelfio, V Ahyong, MH Akabas, P Alano, ...
PLoS pathogens 12 (7), e1005763, 2016
1982016
Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains
NK Williams, RS Bamert, O Patel, C Wang, PM Walden, AF Wilks, ...
Journal of molecular biology 387 (1), 219-232, 2009
1912009
Cytological and biochemical characterization of the FtsA cell division protein of Bacillus subtilis
A Feucht, I Lucet, MD Yudkin, J Errington
Molecular microbiology 40 (1), 115-125, 2001
1752001
The molecular basis of JAK/STAT inhibition by SOCS1
NPD Liau, A Laktyushin, IS Lucet, JM Murphy, S Yao, E Whitlock, ...
Nature communications 9 (1), 1-14, 2018
1422018
HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death
AV Jacobsen, KN Lowes, MC Tanzer, IS Lucet, JM Hildebrand, EJ Petrie, ...
Cell death & disease 7 (1), e2051-e2051, 2016
1002016
Direct interaction between the cell division protein FtsZ and the cell differentiation protein SpoIIE
I Lucet, A Feucht, MD Yudkin, J Errington
The EMBO Journal 19 (7), 1467-1475, 2000
902000
Plasmodium kinases as targets for new-generation antimalarials
IS Lucet, A Tobin, D Drewry, AF Wilks, C Doerig
Future medicinal chemistry 4 (18), 2295-2310, 2012
882012
Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL
JM Murphy, IS Lucet, JM Hildebrand, MC Tanzer, SN Young, P Sharma, ...
Biochemical Journal 457 (3), 369-377, 2014
852014
Genome-wide binding and mechanistic analyses of Smchd1-mediated epigenetic regulation
K Chen, J Hu, DL Moore, R Liu, SA Kessans, K Breslin, IS Lucet, A Keniry, ...
Proceedings of the National Academy of Sciences 112 (27), E3535-E3544, 2015
842015
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
EJ Petrie, JJ Sandow, AV Jacobsen, BJ Smith, MDW Griffin, IS Lucet, ...
Nature communications 9 (1), 1-15, 2018
832018
Molecular mechanism of CCAAT-enhancer binding protein recruitment by the TRIB1 pseudokinase
JM Murphy, Y Nakatani, SA Jamieson, W Dai, IS Lucet, PD Mace
Structure 23 (11), 2111-2121, 2015
762015
The 2.7 crystal structure of the autoinhibited human c-Fms kinase domain
M Walter, IS Lucet, O Patel, SE Broughton, R Bamert, NK Williams, ...
Journal of molecular biology 367 (3), 839-847, 2007
692007
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