| Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans K Linke, PD Mace, CA Smith, DL Vaux, J Silke, CL Day Cell death & differentiation 15 (5), 841-848, 2008 | 343 | 2008 |
| TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (TNF) to efficiently activate NF-κB and to prevent TNF-induced apoptosis JE Vince, D Pantaki, R Feltham, PD Mace, SM Cordier, AC Schmukle, ... Journal of Biological Chemistry 284 (51), 35906, 2009 | 277 | 2009 |
| Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment PD Mace, K Linke, R Feltham, FR Schumacher, CA Smith, DL Vaux, ... Journal of Biological Chemistry 283 (46), 31633-31640, 2008 | 197 | 2008 |
| The CARD plays a critical role in ASC foci formation and inflammasome signalling M Proell, M Gerlic, PD Mace, JC Reed, SJ Riedl Biochemical Journal 449 (3), 613-621, 2013 | 188 | 2013 |
| Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization R Feltham, B Bettjeman, R Budhidarmo, PD Mace, S Shirley, SM Condon, ... Journal of Biological Chemistry 286 (19), 17015-17028, 2011 | 184 | 2011 |
| Structure of a HOIP/E2~ ubiquitin complex reveals RBR E3 ligase mechanism and regulation BC Lechtenberg, A Rajput, R Sanishvili, MK Dobaczewska, CF Ware, ... Nature 529 (7587), 546-550, 2016 | 180 | 2016 |
| Assembling the building blocks: structure and function of inhibitor of apoptosis proteins PD Mace, S Shirley, CL Day Cell Death & Differentiation 17 (1), 46-53, 2010 | 133 | 2010 |
| Structural mechanisms in NLR inflammasome signaling BC Lechtenberg, PD Mace, SJ Riedl Current opinion in structural biology 29, 17-25, 2014 | 127 | 2014 |
| Molecular mechanism of CCAAT-enhancer binding protein recruitment by the TRIB1 pseudokinase JM Murphy, Y Nakatani, SA Jamieson, W Dai, IS Lucet, PD Mace Structure 23 (11), 2111-2121, 2015 | 115 | 2015 |
| Molecular cell death platforms and assemblies PD Mace, SJ Riedl Current opinion in cell biology 22 (6), 828-836, 2010 | 105 | 2010 |
| Live and let die: insights into pseudoenzyme mechanisms from structure JM Murphy, PD Mace, PA Eyers Current opinion in structural biology 47, 95-104, 2017 | 103 | 2017 |
| Activation and specificity of human caspase-10 K Wachmann, C Pop, BJ van Raam, M Drag, PD Mace, SJ Snipas, ... Biochemistry 49 (38), 8307-8315, 2010 | 100 | 2010 |
| Asymmetric recruitment of cIAPs by TRAF2 PD Mace, C Smits, DL Vaux, J Silke, CL Day Journal of molecular biology 400 (1), 8-15, 2010 | 93 | 2010 |
| Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK PD Mace, Y Wallez, MF Egger, MK Dobaczewska, H Robinson, ... Nature communications 4 (1), 1681, 2013 | 79 | 2013 |
| Identification of highly selective covalent inhibitors by phage display S Chen, S Lovell, S Lee, M Fellner, PD Mace, M Bogyo Nature biotechnology 39 (4), 490-498, 2021 | 68 | 2021 |
| Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP M Vamos, K Welsh, D Finlay, PS Lee, PD Mace, SJ Snipas, ML Gonzalez, ... ACS chemical biology 8 (4), 725-732, 2013 | 66 | 2013 |
| High resolution structures of the bone morphogenetic protein type II receptor in two crystal forms: implications for ligand binding PD Mace, JF Cutfield, SM Cutfield Biochemical and biophysical research communications 351 (4), 831-838, 2006 | 66 | 2006 |
| When worlds collide—mechanisms at the interface between phosphorylation and ubiquitination P Filipčík, JR Curry, PD Mace Journal of molecular biology 429 (8), 1097-1113, 2017 | 64 | 2017 |
| Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1 SA Jamieson, Z Ruan, AE Burgess, JR Curry, HD McMillan, JL Brewster, ... Science signaling 11 (549), eaau0597, 2018 | 59 | 2018 |
| Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity JD Wright, PD Mace, CL Day Nature structural & molecular biology 23 (1), 45-52, 2016 | 56 | 2016 |
