| Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and … JB de Haan, C Bladier, P Griffiths, M Kelner, RD O'Shea, NS Cheung, ... Journal of Biological Chemistry 273 (35), 22528-22536, 1998 | 597 | 1998 |
| NADPH oxidase 1 plays a key role in diabetes mellitus–accelerated atherosclerosis SP Gray, E Di Marco, J Okabe, C Szyndralewiez, F Heitz, AC Montezano, ... Circulation 127 (18), 1888-1902, 2013 | 437 | 2013 |
| Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide JB De Haan, F Cristiano, R Iannello, C Bladier, MJ Kelner, I Kola Human molecular genetics 5 (2), 283-292, 1996 | 270 | 1996 |
| Lack of the antioxidant enzyme glutathione peroxidase-1 accelerates atherosclerosis in diabetic apolipoprotein E–deficient mice P Lewis, N Stefanovic, J Pete, AC Calkin, S Giunti, V Thallas-Bonke, ... Circulation 115 (16), 2178-2187, 2007 | 267 | 2007 |
| Increased infarct size and exacerbated apoptosis in the glutathione peroxidase‐1 (Gpx‐1) knockout mouse brain in response to ischemia/reperfusion injury PJ Crack, JM Taylor, NJ Flentjar, J De Haan, P Hertzog, RC Iannello, ... Journal of neurochemistry 78 (6), 1389-1399, 2001 | 256 | 2001 |
| Response of a primary human fibroblast cell line to H2O2: senescence-like growth arrest or apoptosis? C Bladier, EJ Wolvetang, P Hutchinson, JB De Haan, I Kola Cell growth & differentiation: the molecular biology journal of the American …, 1997 | 230 | 1997 |
| Cu/Zn-superoxide dismutase and glutathione peroxidase during aging. JB De Haan, F Cristiano, RC Iannello, I Kola Biochemistry and molecular biology international 35 (6), 1281-1297, 1995 | 201 | 1995 |
| Oxidative stress and NLRP3-inflammasome activity as significant drivers of diabetic cardiovascular complications: therapeutic implications A Sharma, M Tate, G Mathew, JE Vince, RH Ritchie, JB De Haan Frontiers in physiology 9, 331431, 2018 | 183 | 2018 |
| Selenium–GPX4 axis protects follicular helper T cells from ferroptosis Y Yao, Z Chen, H Zhang, C Chen, M Zeng, J Yunis, Y Wei, Y Wan, ... Nature immunology 22 (9), 1127-1139, 2021 | 182 | 2021 |
| Nrf2 activators as attractive therapeutics for diabetic nephropathy JB De Haan Diabetes 60 (11), 2683, 2011 | 170 | 2011 |
| Recent novel approaches to limit oxidative stress and inflammation in diabetic complications RJ Pickering, CJ Rosado, A Sharma, S Buksh, M Tate, JB de Haan Clinical & translational immunology 7 (4), e1016, 2018 | 164 | 2018 |
| Targeting mitochondria and reactive oxygen species-driven pathogenesis in diabetic nephropathy R Lindblom, G Higgins, M Coughlan, JB de Haan The review of diabetic studies: RDS 12 (1-2), 134, 2015 | 137 | 2015 |
| Oxidative stress in surgery in an ageing population: pathophysiology and therapy F Rosenfeldt, M Wilson, G Lee, C Kure, R Ou, L Braun, J de Haan Experimental gerontology 48 (1), 45-54, 2013 | 137 | 2013 |
| Antiatherosclerotic and renoprotective effects of ebselen in the diabetic apolipoprotein E/GPx1-double knockout mouse P Chew, DYC Yuen, N Stefanovic, J Pete, MT Coughlan, ... Diabetes 59 (12), 3198-3207, 2010 | 134 | 2010 |
| Effects of sodium butyrate on the synthesis and methylation of DNA in normal cells and their transformed counterparts JB De Haan, W Gevers, MI Parker Cancer research 46 (2), 713-716, 1986 | 126 | 1986 |
| Cu/Zn superoxide dismutase mRNA and enzyme activity, and susceptibility to lipid peroxidation, increases with aging in murine brains JB de Haan, JD Newman, I Kola Molecular brain research 13 (3), 179-187, 1992 | 123 | 1992 |
| Derivative of bardoxolone methyl, dh404, in an inverse dose-dependent manner lessens diabetes-associated atherosclerosis and improves diabetic kidney disease SM Tan, A Sharma, N Stefanovic, DYC Yuen, TC Karagiannis, C Meyer, ... Diabetes 63 (9), 3091-3103, 2014 | 115 | 2014 |
| Targeting endothelial dysfunction in vascular complications associated with diabetes A Sharma, PN Bernatchez, JB De Haan International journal of vascular medicine 2012, 2012 | 114 | 2012 |
| Oxidative stress and neural dysfunction in Down syndrome RC Iannello, PJ Crack, JB De Haan, I Kola The Molecular Biology of Down Syndrome, 257-267, 1999 | 113 | 1999 |
| An imbalance in antioxidant defense affects cellular function: the pathophysiological consequences of a reduction in antioxidant defense in the glutathione peroxidase-1 (Gpx1 … JB De Haan, PJ Crack, N Flentjar, RC Iannello, PJ Hertzog, I Kola Redox Report 8 (2), 69-79, 2003 | 112 | 2003 |
