| A structural analysis of M protein in coronavirus assembly and morphology BW Neuman, G Kiss, AH Kunding, D Bhella, MF Baksh, S Connelly, ... Journal of structural biology 174 (1), 11-22, 2011 | 1005 | 2011 |
| Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade CE Bulawa, S Connelly, M DeVit, L Wang, C Weigel, JA Fleming, ... Proceedings of the National Academy of Sciences, 2012 | 715 | 2012 |
| The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug SM Johnson, S Connelly, C Fearns, ET Powers, JW Kelly Journal of Molecular Biology, 2012 | 363 | 2012 |
| Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses S Connelly, S Choi, SM Johnson, JW Kelly, IA Wilson Current opinion in structural biology 20 (1), 54-62, 2010 | 197 | 2010 |
| AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin SC Penchala, S Connelly, Y Wang, MS Park, L Zhao, A Baranczak, ... Proceedings of the National Academy of Sciences 110 (24), 9992-9997, 2013 | 163 | 2013 |
| Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors SM Johnson, S Connelly, IA Wilson, JW Kelly Journal of medicinal chemistry 51 (2), 260-270, 2008 | 159 | 2008 |
| Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate NP Grimster, S Connelly, A Baranczak, J Dong, LB Krasnova, ... Journal of the American Chemical Society 135 (15), 5656-5668, 2013 | 158 | 2013 |
| Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma S Choi, S Connelly, N Reixach, IA Wilson, JW Kelly Nature chemical biology 6 (2), 133-139, 2010 | 106 | 2010 |
| A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans A Baranczak, Y Liu, S Connelly, WGH Du, ER Greiner, JC Genereux, ... Journal of the American Chemical Society 137 (23), 7404-7414, 2015 | 99 | 2015 |
| Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies SM Johnson, S Connelly, IA Wilson, JW Kelly Journal of medicinal chemistry 51 (20), 6348-6358, 2008 | 96 | 2008 |
| Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity MM Alhamadsheh, S Connelly, A Cho, N Reixach, ET Powers, DW Pan, ... Science translational medicine 3 (97), 97ra81-97ra81, 2011 | 95 | 2011 |
| Akt phosphorylation and regulation of transketolase is a nodal point for amino acid control of purine synthesis A Saha, S Connelly, J Jiang, S Zhuang, DT Amador, T Phan, RB Pilz, ... Molecular cell 55 (2), 264-276, 2014 | 84 | 2014 |
| Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol N Proisy, SY Sharp, K Boxall, S Connelly, SM Roe, C Prodromou, ... Chemistry & biology 13 (11), 1203-1215, 2006 | 84 | 2006 |
| A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity S Choi, N Reixach, S Connelly, SM Johnson, IA Wilson, JW Kelly Journal of the American Chemical Society 132 (4), 1359-1370, 2010 | 73 | 2010 |
| The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis W Wang, A Fridman, W Blackledge, S Connelly, IA Wilson, RB Pilz, ... Journal of biological chemistry 284 (6), 3521-3528, 2009 | 71 | 2009 |
| Natural methods of protein stabilization: thermostable biocatalysts JA Littlechild, J Guy, S Connelly, L Mallett, S Waddell, CA Rye, K Line, ... Biochemical Society Transactions 35 (6), 1558-1563, 2007 | 66 | 2007 |
| Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies SM Johnson, S Connelly, IA Wilson, JW Kelly Journal of medicinal chemistry 52 (4), 1115-1125, 2009 | 58 | 2009 |
| Stabilizing the CH2 Domain of an Antibody by Engineering in an Enhanced Aromatic Sequon W Chen, L Kong, S Connelly, JM Dendle, Y Liu, IA Wilson, ET Powers, ... ACS chemical biology 11 (7), 1852-1861, 2016 | 49 | 2016 |
| Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors N Myung, S Connelly, B Kim, SJ Park, IA Wilson, JW Kelly, S Choi Chemical communications 49 (80), 9188-9190, 2013 | 41 | 2013 |
| Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis EH Suh, Y Liu, S Connelly, JC Genereux, IA Wilson, JW Kelly Journal of the American Chemical Society 135 (47), 17869-17880, 2013 | 37 | 2013 |
