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Lars Aagaard
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RNAi therapeutics: principles, prospects and challenges
L Aagaard, JJ Rossi
Advanced drug delivery reviews 59 (2-3), 75-86, 2007
11592007
Distance constraints between microRNA target sites dictate efficacy and cooperativity
P Sætrom, BSE Heale, O Snøve Jr, L Aagaard, J Alluin, JJ Rossi
Nucleic acids research 35 (7), 2333-2342, 2007
4502007
The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells
MS Weinberg, LM Villeneuve, ALI Ehsani, M Amarzguioui, L Aagaard, ...
Rna 12 (2), 256-262, 2006
3722006
Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC
D Castanotto, K Sakurai, R Lingeman, H Li, L Shively, L Aagaard, H Soifer, ...
Nucleic acids research 35 (15), 5154-5164, 2007
3282007
Identification of endogenous retroviral reading frames in the human genome
P Villesen, L Aagaard, C Wiuf, FS Pedersen
Retrovirology 1, 1-13, 2004
2282004
Mesenchymal stem cells derived from human induced pluripotent stem cells retain adequate osteogenicity and chondrogenicity but less adipogenicity
R Kang, Y Zhou, S Tan, G Zhou, L Aagaard, L Xie, C Bünger, L Bolund, ...
Stem cell research & therapy 6, 1-14, 2015
1242015
B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity
T Brudek, T Christensen, L Aagaard, T Petersen, HJ Hansen, ...
Retrovirology 6, 1-13, 2009
1122009
Molecular mechanisms in DM1—a focus on foci
OJ Pettersson, L Aagaard, TG Jensen, CK Damgaard
Nucleic acids research 43 (4), 2433-2441, 2015
1042015
A facile lentiviral vector system for expression of doxycycline-inducible shRNAs: knockdown of the pre-miRNA processing enzyme Drosha
L Aagaard, M Amarzguioui, G Sun, LC Santos, A Ehsani, H Prydz, ...
Molecular Therapy 15 (5), 938-945, 2007
782007
Suppression of choroidal neovascularization by AAV-based dual-acting antiangiogenic gene therapy
AL Askou, S Alsing, JNE Benckendorff, A Holmgaard, JG Mikkelsen, ...
Molecular Therapy-Nucleic Acids 16, 38-50, 2019
572019
DDX6 regulates sequestered nuclear CUG-expanded DMPK-mRNA in dystrophia myotonica type 1
OJ Pettersson, L Aagaard, D Andrejeva, R Thomsen, TG Jensen, ...
Nucleic acids research 42 (11), 7186-7200, 2014
552014
Multigenic lentiviral vectors for combined and tissue-specific expression of miRNA-and protein-based antiangiogenic factors
AL Askou, L Aagaard, C Kostic, Y Arsenijevic, AK Hollensen, T Bek, ...
Molecular Therapy Methods & Clinical Development 2, 2015
502015
Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution
AL Kjeldbjerg, P Villesen, L Aagaard, FS Pedersen
BMC Evolutionary Biology 8, 1-11, 2008
502008
Enhanced genome editing in mammalian cells with a modified dual-fluorescent surrogate system
Y Zhou, Y Liu, D Hussmann, P Brøgger, RA Al-Saaidi, S Tan, L Lin, ...
Cellular and Molecular Life Sciences 73, 2543-2563, 2016
482016
Adeno‐associated virus‐delivered polycistronic microRNA‐clusters for knockdown of vascular endothelial growth factor in vivo
M Pihlmann, AL Askou, L Aagaard, GH Bruun, JD Svalgaard, ...
The journal of gene medicine 14 (5), 328-338, 2012
452012
Rational design of micro-RNA-like bifunctional siRNAs targeting HIV and the HIV coreceptor CCR5
A Ehsani, P Saetrom, J Zhang, J Alluin, H Li, O Snøve Jr, L Aagaard, ...
Molecular Therapy 18 (4), 796-802, 2010
292010
Suppression of choroidal neovascularization in mice by subretinal delivery of multigenic lentiviral vectors encoding anti-angiogenic microRNAs
AL Askou, JNE Benckendorff, A Holmgaard, T Storm, L Aagaard, T Bek, ...
Human gene therapy methods 28 (4), 222-233, 2017
282017
Improved lentiviral gene delivery to mouse liver by hydrodynamic vector injection through tail vein
T Dalsgaard, CR Cecchi, AL Askou, RO Bak, PO Andersen, D Hougaard, ...
Molecular Therapy-Nucleic Acids 12, 672-683, 2018
262018
Mitochondrial spare respiratory capacity is negatively correlated with nuclear reprogramming efficiency
Y Zhou, RA Al-Saaidi, P Fernandez-Guerra, KK Freude, RKJ Olsen, ...
Stem cells and development 26 (3), 166-176, 2017
252017
The∼ 30-million-year-old ERVPb1 envelope gene is evolutionarily conserved among hominoids and Old World monkeys
L Aagaard, P Villesen, AL Kjeldbjerg, FS Pedersen
Genomics 86 (6), 685-691, 2005
232005
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Articles 1–20