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Jason R. Spence
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SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
CGK Ziegler, SJ Allon, SK Nyquist, IM Mbano, VN Miao, CN Tzouanas, ...
Cell 181 (5), 1016-1035. e19, 2020
23212020
Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
JR Spence, CN Mayhew, SA Rankin, MF Kuhar, JE Vallance, K Tolle, ...
Nature 470 (7332), 105-109, 2011
19552011
Modelling human development and disease in pluripotent stem-cell-derived gastric organoids
KW McCracken, EM Catá, CM Crawford, KL Sinagoga, M Schumacher, ...
Nature 516 (7531), 400-404, 2014
9902014
In vitro generation of human pluripotent stem cell derived lung organoids
BR Dye, DR Hill, MAH Ferguson, YH Tsai, MS Nagy, R Dyal, JM Wells, ...
elife 4, e05098, 2015
7552015
An in vivo model of human small intestine using pluripotent stem cells
CL Watson, MM Mahe, J Múnera, JC Howell, N Sundaram, HM Poling, ...
Nature medicine 20 (11), 1310-1314, 2014
5552014
Facile isolation and the characterization of human retinal stem cells
BLK Coles, B Angénieux, T Inoue, K Del Rio-Tsonis, JR Spence, ...
Proceedings of the National Academy of Sciences 101 (44), 15772-15777, 2004
5002004
Synthetic hydrogels for human intestinal organoid generation and colonic wound repair
R Cruz-Acuña, M Quirós, AE Farkas, PH Dedhia, S Huang, D Siuda, ...
Nature cell biology 19 (11), 1326-1335, 2017
4632017
Generating human intestinal tissue from pluripotent stem cells in vitro
KW McCracken, JC Howell, JM Wells, JR Spence
Nature protocols 6 (12), 1920-1928, 2011
4482011
Sox17 and Sox4 differentially regulate β-catenin/T-cell factor activity and proliferation of colon carcinoma cells
D Sinner, JJ Kordich, JR Spence, R Opoka, S Rankin, SCJ Lin, D Jonatan, ...
Molecular and cellular biology 27 (22), 7802-7815, 2007
3782007
Sox17 regulates organ lineage segregation of ventral foregut progenitor cells
JR Spence, AW Lange, SCJ Lin, KH Kaestner, AM Lowy, I Kim, ...
Developmental cell 17 (1), 62-74, 2009
3342009
Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function
JL Leslie, S Huang, JS Opp, MS Nagy, M Kobayashi, VB Young, ...
Infection and immunity 83 (1), 138-145, 2015
3282015
Generation of lung organoids from human pluripotent stem cells in vitro
AJ Miller, BR Dye, D Ferrer-Torres, DR Hill, AW Overeem, LD Shea, ...
Nature protocols 14 (2), 518-540, 2019
3212019
Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells, and plasmablasts as hallmarks of severe COVID-19
JP Bernardes, N Mishra, F Tran, T Bahmer, L Best, JI Blase, D Bordoni, ...
Immunity 53 (6), 1296-1314. e9, 2020
2952020
Organoid models of human gastrointestinal development and disease
PH Dedhia, N Bertaux-Skeirik, Y Zavros, JR Spence
Gastroenterology 150 (5), 1098-1112, 2016
2732016
Sox9 plays multiple roles in the lung epithelium during branching morphogenesis
BE Rockich, SM Hrycaj, HP Shih, MS Nagy, MAH Ferguson, JL Kopp, ...
Proceedings of the National Academy of Sciences 110 (47), E4456-E4464, 2013
2722013
Differentiation of human pluripotent stem cells into colonic organoids via transient activation of BMP signaling
JO Múnera, N Sundaram, SA Rankin, D Hill, C Watson, M Mahe, ...
Cell stem cell 21 (1), 51-64. e6, 2017
2422017
Transcriptome-wide analysis reveals hallmarks of human intestine development and maturation in vitro and in vivo
SR Finkbeiner, DR Hill, CH Altheim, PH Dedhia, MJ Taylor, YH Tsai, ...
Stem cell reports 4 (6), 1140-1155, 2015
2362015
Vertebrate intestinal endoderm development
JR Spence, R Lauf, NF Shroyer
Developmental dynamics 240 (3), 501-520, 2011
2312011
Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche
Y Shao, K Taniguchi, K Gurdziel, RF Townshend, X Xue, KMA Yong, ...
Nature materials 16 (4), 419-425, 2017
2172017
How to make an intestine
JM Wells, JR Spence
Development 141 (4), 752-760, 2014
2092014
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