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Patrick Sexton
Patrick Sexton
Verified email at monash.edu
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Cited by
Cited by
Year
Functional selectivity and classical concepts of quantitative pharmacology
JD Urban, WP Clarke, M Von Zastrow, DE Nichols, B Kobilka, H Weinstein, ...
Journal of Pharmacology and Experimental Therapeutics 320 (1), 1-13, 2007
13022007
International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors
DR Poyner, PM Sexton, I Marshall, DM Smith, R Quirion, W Born, R Muff, ...
Pharmacological reviews 54 (2), 233-246, 2002
9542002
Activation and allosteric modulation of a muscarinic acetylcholine receptor
AC Kruse, AM Ring, A Manglik, J Hu, K Hu, K Eitel, H Hübner, E Pardon, ...
Nature 504 (7478), 101-106, 2013
9352013
Allosteric modulation of G protein–coupled receptors
LT May, K Leach, PM Sexton, A Christopoulos
Annu. Rev. Pharmacol. Toxicol. 47, 1-51, 2007
7872007
Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization.
GC Nicholson, JM Moseley, PM Sexton, FA Mendelsohn, TJ Martin
The Journal of clinical investigation 78 (2), 355-360, 1986
5771986
Mechanisms of signalling and biased agonism in G protein-coupled receptors
D Wootten, A Christopoulos, M Marti-Solano, MM Babu, PM Sexton
Nature reviews Molecular cell biology 19 (10), 638-653, 2018
5682018
Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product
G Christopoulos, KJ Perry, M Morfis, N Tilakaratne, Y Gao, NJ Fraser, ...
Molecular pharmacology 56 (1), 235-242, 1999
5541999
G-protein–coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor
E Kostenis, G Milligan, A Christopoulos, CF Sanchez-Ferrer, ...
Circulation 111 (14), 1806-1813, 2005
5342005
Emerging paradigms in GPCR allostery: implications for drug discovery
D Wootten, A Christopoulos, PM Sexton
Nature reviews Drug discovery 12 (8), 630-644, 2013
5032013
Phase-plate cryo-EM structure of a class B GPCR–G-protein complex
YL Liang, M Khoshouei, M Radjainia, Y Zhang, A Glukhova, J Tarrasch, ...
Nature 546 (7656), 118-123, 2017
4782017
Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs
RO Dror, HF Green, C Valant, DW Borhani, JR Valcourt, AC Pan, ...
Nature 503 (7475), 295-299, 2013
4262013
Muscarinic acetylcholine receptors: novel opportunities for drug development
AC Kruse, BK Kobilka, D Gautam, PM Sexton, A Christopoulos, J Wess
Nature reviews Drug discovery 13 (7), 549-560, 2014
4232014
Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology
K Leach, PM Sexton, A Christopoulos
Trends in pharmacological sciences 28 (8), 382-389, 2007
3802007
Novel receptor partners and function of receptor activity-modifying proteins
A Christopoulos, G Christopoulos, M Morfis, M Udawela, M Laburthe, ...
Journal of Biological Chemistry 278 (5), 3293-3297, 2003
3502003
Crystal structures of the M1 and M4 muscarinic acetylcholine receptors
DM Thal, B Sun, D Feng, V Nawaratne, K Leach, CC Felder, MG Bures, ...
Nature 531 (7594), 335, 2016
3332016
Structure of the adenosine-bound human adenosine A1 receptor–Gi complex
CJ Draper-Joyce, M Khoshouei, DM Thal, YL Liang, ATN Nguyen, ...
Nature 558 (7711), 559-563, 2018
3192018
The role of kinetic context in apparent biased agonism at GPCRs
C Klein Herenbrink, DA Sykes, P Donthamsetti, M Canals, T Coudrat, ...
Nature communications 7 (1), 10842, 2016
3162016
In vitro autoradiographic localization of amylin binding sites in rat brain
PM Sexton, G Paxinos, MA Kenney, PJ Wookey, K Beaumont
Neuroscience 62 (2), 553-567, 1994
3111994
Glucagon-like peptide-1 and its class BG protein–coupled receptors: a long march to therapeutic successes
C De Graaf, D Donnelly, D Wootten, J Lau, PM Sexton, LJ Miller, JM Ahn, ...
Pharmacological reviews 68 (4), 954-1013, 2016
2992016
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex
YL Liang, M Khoshouei, A Glukhova, SGB Furness, P Zhao, L Clydesdale, ...
Nature 555 (7694), 121-125, 2018
2962018
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